Evidence map›Paper›PMID 39851112›Full record

ArticleCurrent medicinal chemistry2025

Thymoquinone-loaded Nanosized Ethosomal-based Hydrogels: Their Preparation, Characterization,

Pratibha Pathak, Waleed H Almalki, Nabil K Alruwaili, Abdulaziz Alzahrani, Salem Salman Almujri, Abdulrahman Alhamyani, Abdulmalik Saleh Alfawaz Altamimi, Ankit Sahoo, Tanuja Singh, Md Abul Barkat and 3 more

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Article in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

13 authors.

Pratibha PathakChanakya College of Pharmacy and Medical Sciences, Near Magistrate Colony, Patna, Bihar, Shrink, 800014, India.
Waleed H AlmalkiDepartment of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Nabil K AlruwailiDepartment of Pharmaceutics, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia.
Abdulaziz AlzahraniPharmaceuticals Chemistry Department, Faculty of Clinical Pharmacy, Al-Baha University, Alaqiq, 65779-7738, Saudi Arabia.
Salem Salman AlmujriDepartment of Pharmacology, College of Pharmacy, King Khalid University, Asir-Abha, 61421, Saudi Arabia.
Abdulrahman AlhamyaniPharmaceuticals Chemistry Department, Faculty of Clinical Pharmacy, Al-Baha University, Alaqiq, 65779-7738, Saudi Arabia.
Abdulmalik Saleh Alfawaz AltamimiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, 11942, Saudi Arabia.
Ankit SahooCollege of Pharmacy, J.S. University, Shikohabad, Firozabad, Uttar Pradesh, 283135, India.
Tanuja SinghCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 10025, India.
Md Abul BarkatDepartment of Pharmaceutics, College of Pharmacy, University of Hafr Al Batin, Al-Batin, 39524, Saudi Arabia.
Vikas KumarDepartment of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, 211007, Uttar Pradesh, India.
Amita VermaDepartment of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, 211007, Uttar Pradesh, India.
Mahfoozur RahmanDepartment of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, 211007, Uttar Pradesh, India.

Funding

Umm-Al-Qura University, Saudi Arabia 25UQU4310387GSSR01
6 · The paper itself

Abstract

backgroundThymoquinone (TQ) is found in the seeds of

aimThe present study focused on a nanosized ethosome formulation of thymoquinone with potent antimicrobial activity against

methodsThis study aimed to develop nanosized TQ-loaded ethosome-based hydrogels and evaluate their antimicrobial effects. The methods included UV‒VIS spectrophotometer analysis, solubility studies, preparation of TQ-loaded ethosomes, thermodynamic stability, in vitro drug release, characterization, preparation of ethosome-based hydrogels,

resultsUV‒VIS analysis revealed that thymoquinone (TQ) demonstrated a maximum absorbance peak at λmax 254 nm. TQ has the highest solubility in ethanol (60 mg/mL) and soy lecithin (65 mg/mL). TQ solubility in PBS 7.4 (75 mg/mL) with ethanol (50:50% w/v) was found to be crucial for determining

conclusionThe E6 hydrogel shows promise for local therapeutic benefits and sustained drug release and could be a superior herbal option for managing skin infections.

Indexed as

Anti-Bacterial AgentsBenzoquinonesHydrogelsNanoparticlesStaphylococcus aureusAnimalsDrug LiberationLiposomesMicrobial Sensitivity TestsParticle SizeSolubilityAnti-Bacterial AgentsBenzoquinonesHydrogelsLiposomesthymoquinonebioavailabilityethosomehydrogelnigella sativaS. aureus.solubilitystabilityThymoquinone

Identifiers

PMID39851112

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