Evidence map›Paper›PMID 39851111›Full record

ReviewCurrent medicinal chemistry2026

Exploring the Therapeutic Potential of Plumbagin: Its Current Applications in Cancer and Neuropsychiatric Disorders.

Tingting Jiang, Dongsheng Zhou, Jiahui Wang, Haitao Huang, Chong Zhang, Jianguo Yan, Yali Zhou

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tingting JiangInstitute of Pathogenic Biology, Guilin Medical University, Guilin, 541004, China.ORCID 0009-0007-9378-6194
Dongsheng ZhouGuangxi Medical and Health Key Disciplines Infectious Diseases Key Disciplines, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541004, China.
Jiahui WangInstitute of Pathogenic Biology, Guilin Medical University, Guilin, 541004, China.ORCID 0009-0007-9378-6194
Haitao HuangInstitute of Pathogenic Biology, Guilin Medical University, Guilin, 541004, China.
Chong ZhangDepartment of Neurology, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541100, China.
Jianguo YanGuangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, 541004, China.ORCID 0000-0003-4601-4830
Yali ZhouInstitute of Pathogenic Biology, Guilin Medical University, Guilin, 541004, China.ORCID 0000-0001-7571-5316

Funding

National Natural Science Foundation of China (NSFC) 82160517, 82460530Natural Science Foundation of Guangxi Province 2023GXNSFAA026213, 2023GXNSFAA026081
6 · The paper itself

Abstract

Plumbagin (PL) is an important natural active ingredient in traditional Chinese medicine derived from the Plumbago zeylanica L. It possesses a variety of biological activities, such as anti-inflammatory, anticancer, antioxidant, antimicrobial, and neuroprotective properties, and has great potential for utilization in disease treatment and prevention. Cancer and neurological and psychiatric diseases are two major categories of diseases that currently threaten the physical and mental health of human beings, and their increasing incidence is causing a serious economic burden to all humanity. Based on the physical and chemical properties and pharmacokinetics of plumbagin, this study will focus on summarizing the application research status of plumbagin in cancer, neurological, and psychiatric diseases and analyze the molecular targets and action pathways of its therapeutic efficacy. This study will also briefly summarize the application of plumbagin in other diseases, as well as the existing problems and future development direction of plumbagin in clinical application, aiming to provide new perspectives and strategies for the development of new drugs and the treatment of existing diseases.

Indexed as

Antineoplastic Agents, PhytogenicMental DisordersNaphthoquinonesNeoplasmsNervous System DiseasesAnimalsHumansNeuroprotective AgentsAntineoplastic Agents, PhytogenicNaphthoquinonesNeuroprotective Agentsplumbagincancerneuroprotection.oxidative stressPlumbaginpsychiatric diseasestraditional Chinese medicine

Identifiers

PMID39851111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.