Evidence map›Paper›PMID 39850903›Full record

ArticleFrontiers in immunology2024

Squamate reptiles may have compensated for the lack of γδTCR with a duplication of the TRB locus.

Jordan M Sampson, Kimberly A Morrissey, Kieran J Mikolajova, Kourtney M Zimmerly, Neil J Gemmell, Michael G Gardner, Terry Bertozzi, Robert D Miller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. A trove of antiviral TRIM family E3 ligases in reptiles.bioRxiv : the preprint server for biology · 2025
    Article
  5. Chromosome-length genome assembly ofbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jordan M SampsonCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, United States.
Kimberly A MorrisseyCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, United States.
Kieran J MikolajovaCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, United States.
Kourtney M ZimmerlyCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, United States.
Neil J GemmellDepartment of Anatomy, University of Otago, Dunedin, New Zealand.
Michael G GardnerCollege of Science and Engineering, Flinders University, Adelaide, SA, Australia.
Terry BertozziSouth Australian Museum, Adelaide, SA, Australia.
Robert D MillerCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, United States.

Funding

National Science Foundation Award IOS-2103367National Science Foundation Graduate Research Fellowship DGE-1939267
6 · The paper itself

Abstract

Squamate reptiles are amongst the most successful terrestrial vertebrate lineages, with over 10,000 species across a broad range of ecosystems. Despite their success, squamates are also amongst the least studied lineages immunologically. Recently, a universal lack of γδ T cells in squamates due to deletions of the genes encoding the T cell receptor (TCR) γ and δ chains was discovered. Here, we begin to address how the loss of γδ T cells may have impacted the evolution of the squamate immune system. Using the skink

Indexed as

Gene DuplicationLizardsReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReptilesAnimalsEvolution, MolecularPhylogenyReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltacomparative immunologygene duplicationgene losssquamateT cells

Identifiers

PMID39850903
PMCPMC11754216

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.