Evidence map›Paper›PMID 39850833›Full record

ArticlePeerJ2025

Genetic determinants of COVID-19 severity and mortality:

João Locke Ferreira de Araújo, Átila Duque Rossi, Jessica Maciel de Almeida, Hugo José Alves, Isabela de Carvalho Leitão, Renata Eliane de Ávila, Anna Carla Pinto Castiñeiras, Jéssica da Silva Oliveira, Rafael Mello Galliez, Marlon Daniel Lima Tonini and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

João Locke Ferreira de AraújoDepartamento de genética, ecologia e evolução, Laboratório de biologia integrativa, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Átila Duque RossiDepartamento de genética, Laboratório de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Jessica Maciel de AlmeidaDepartamento de genética, Laboratório de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Hugo José AlvesDepartamento de genética, ecologia e evolução, Laboratório de biologia integrativa, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Isabela de Carvalho LeitãoNúcleo de Enfrentamento e Estudos de Doenças Infecciosas Emergentes e Reemergentes (NEEDIER), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Renata Eliane de ÁvilaHospital Eduardo de Menezes, Belo Horizonte, Minas Gerais, Brazil.
Anna Carla Pinto CastiñeirasNúcleo de Enfrentamento e Estudos de Doenças Infecciosas Emergentes e Reemergentes (NEEDIER), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Jéssica da Silva OliveiraMarinha do Brasil, Instituto de Pesquisas Biomédicas, Hospital Naval Marcilio Dias, Rio de Janeiro, Rio de Janeiro, Brazil.
Rafael Mello GalliezNúcleo de Enfrentamento e Estudos de Doenças Infecciosas Emergentes e Reemergentes (NEEDIER), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Marlon Daniel Lima ToniniMarinha do Brasil, Instituto de Pesquisas Biomédicas, Hospital Naval Marcilio Dias, Rio de Janeiro, Rio de Janeiro, Brazil.
Débora Souza FaffeNúcleo de Enfrentamento e Estudos de Doenças Infecciosas Emergentes e Reemergentes (NEEDIER), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Shana Priscila Coutinho Barroso BarrosoMarinha do Brasil, Instituto de Pesquisas Biomédicas, Hospital Naval Marcilio Dias, Rio de Janeiro, Rio de Janeiro, Brazil.
Gustavo Gomes ResendeHospital das Clínicas, (HC-UFMG/EBSERH), Belo Horizonte, MG, Brazil, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Cássia Cristina Alves GonçalvesDepartamento de genética, Laboratório de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Terezinha Marta Pereira Pinto CastiñeirasNúcleo de Enfrentamento e Estudos de Doenças Infecciosas Emergentes e Reemergentes (NEEDIER), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Amilcar TanuriDepartamento de genética, Laboratório de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Mauro Martins TeixeiraDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Renato Santana AguiarDepartamento de genética, ecologia e evolução, Laboratório de biologia integrativa, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Cynthia Chester CardosoDepartamento de genética, Laboratório de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Renan Pedra de SouzaDepartamento de genética, ecologia e evolução, Laboratório de biologia integrativa, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) are central human molecules in the SARS-CoV-2 virus-host interaction. Evidence indicates that Methods: Swabs were collected in two Brazilian cities in 2020: Belo Horizonte ( Results: The median age differed between clinical sites (

Indexed as

Angiotensin-Converting Enzyme 2COVID-19Peptidyl-Dipeptidase ASerine EndopeptidasesAdultAgedAlu ElementsBrazilFemaleHospitalizationHumansMaleMiddle AgedPolymorphism, GeneticSARS-CoV-2Severity of Illness IndexACE2 protein, humanACE protein, humanAngiotensin-Converting Enzyme 2Peptidyl-Dipeptidase ASerine EndopeptidasesTMPRSS2 protein, humanBiomarkersGenetic associationGenetic variabilityIndelMolecular epidemiology

Identifiers

PMID39850833
PMCPMC11756369

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.