Evidence map›Paper›PMID 39850640›Full record

ArticleConference proceedings. International Conference on Image Formation in X-Ray Computed Tomography2024

Double bowtie design for high sensitivity pediatric spectral CT.

Olivia F Sandvold, Yinglin Ge, Roland Proksa, Peter B Noël

Abstract read
In one paragraph

Article in Conference proceedings. International Conference on Image Formation in X-Ray Computed Tomography, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Olivia F SandvoldDepartment of Radiology, Perelman School of Medicine, Philadelphia, PA USA.
Yinglin GeDepartment of Radiology, Perelman School of Medicine, Philadelphia, PA USA.
Roland ProksaDepartment of Radiology, Perelman School of Medicine, Philadelphia, PA USA.
Peter B NoëlDepartment of Radiology, Perelman School of Medicine, Philadelphia, PA USA.

Funding

Patient-specific, high-sensitivity spectral CT for assessment of pancreatic cancerR01EB030494 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI GANG, JIANAN GRACE, NOËL, PETER B · 2021 to 2024
$2.4M
NIBIB NIH HHS R01 EB030494
6 · The paper itself

Abstract

Despite the evident benefits of spectral computed tomography (CT) in delivering qualitative imaging superior to that of conventional CT in adults, its application in pediatric diagnostic imaging is still relatively limited due to various reasons, including design limitations and radiation dose considerations. The use of specialized K-edge filters, in conjunction with other spectral technologies, has been demonstrated to improve spectral quantification accuracy. X-ray flux limitations generally pose challenges in these concepts when applied to adults. However, such limitations are not present in pediatric imaging, allowing the full exploitation of K-edge filters to improve performance. To facilitate the adoption of spectral CT's benefits, as seen in the adult population, into pediatric settings, we introduce an innovative double bowtie filter design. This design incorporates a K-edge material coupled with Teflon and is integrated with rapid kVp-switching technology. A Python simulation was built to model a rapid kVp-switching x-ray tube and to estimate Cramer-Rao lower bound (CRLB) noise in photoelectric and Compton scatter basis domains. We estimate a conventional bowtie filter and corresponding reference patient dose before optimizing double bowtie configurations to contain the highest obtainable spectral signal-to-noise content for the specified phantom. Our findings indicate that an optimal combination of holmium and Teflon in the filter geometry can increase spectral SNR up to twofold the conventional estimates, while still maintaining low radiation dose exposure. This study broadens the scope for pediatric patients to fully benefit from the capabilities of spectral CT.

Indexed as

pediatric imagingquantitative imagingSpectral CTx-ray beam filtration

Identifiers

PMID39850640
PMCPMC11754965

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.