Evidence map›Paper›PMID 39850117›Full record

ArticleIranian journal of basic medical sciences2025

Regeneration of the skin wound by two different crosslinkers:

Naimeh Mahheidari, Morteza Alizadeh, Mohamad Kamalabadi Farahani, Zohreh Arabpour, Nariman Rezaei Kolarijani, Ali R Djalilian, Majid Salehi

Abstract read
In one paragraph

Article in Iranian journal of basic medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Enhancing Wound Healing with a Novel Alginate/Eggshell Membrane-Based Hydrogel Enriched with Red Ginseng Roots and Centella Asiatica.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Naimeh MahheidariStudent Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Morteza AlizadehDepartment of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran.
Mohamad Kamalabadi FarahaniTissue Engineering and stem cells research center, Shahroud University of Medical Sciences, Shahroud, Iran.
Zohreh ArabpourDepartment of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL 60612, USA.
Nariman Rezaei KolarijaniStudent Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Ali R DjalilianDepartment of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL 60612, USA.
Majid SalehiTissue Engineering and stem cells research center, Shahroud University of Medical Sciences, Shahroud, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: For designing a suitable hydrogel, two crosslinked Alginate/ Carboxymethyl cellulose (Alg/CMC) hydrogel, using calcium chloride (Ca Materials and Methods: All samples were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Blood compatibility (BC), Blood clotting index (BCI), weight loss (WL), water absorption (WA), pH, and Electrochemical Impedance Spectroscopy (EIS). Cell viability and cell migration were investigated using the MTT assay and the wound scratch test, respectively. Besides, the wound healing potential of prepared hydrogels was evaluated on the rat models with full-thickness skin excision. To further investigation, TGF β1, IGF-I, COL1, ACT-A (alfa-SMA), and GAPDH expression levels were also reported by RT-PCR. Results: Water absorption and weight loss properties were compared between different crosslinker agents, and the most nontoxic crosslinker concentration was determined. We have shown that GA (20 µl/ml) and Ca Conclusion: This research shows that Ca

Indexed as

AlginateCaCl2Carboxymethyl celluloseGlutaraldehydeTissue engineering

Identifiers

PMID39850117
PMCPMC11756729

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.