Evidence map›Paper›PMID 39849940›Full record

ArticleJournal of natural products2025

Neuromodulating Alkaloids from Millipede Defensive Secretions.

Carla Menegatti, Jared S Wood, Paige Banks, Kenneth Knott, Jonathan S Briganti, Anthony J Briganti, Samuel V G McNally, Paul E Marek, Anne M Brown, Tappey H Jones and 2 more

Abstract read
In one paragraph

Article in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The Discovery of Complex Heterocycles from Millipede Secretions.Journal of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carla MenegattiDepartment of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.
Jared S WoodDepartment of Chemistry & Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28403, United States.ORCID 0000-0002-3940-0461
Paige BanksDepartment of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.
Kenneth KnottDepartment of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.
Jonathan S BrigantiDepartment of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.
Anthony J BrigantiDepartment of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.
Samuel V G McNallyCondor Country Consulting, Inc, Martinez, California 94553, United States.ORCID 0000-0003-4577-9700
Paul E MarekDepartment of Entomology, Virginia Tech, Blacksburg, Virginia 24061, United States.
Anne M BrownDepartment of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0001-6951-8228
Tappey H JonesDepartment of Chemistry, Virginia Military Institute, Lexington, Virginia 24450, United States.
R Thomas WilliamsonDepartment of Chemistry & Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28403, United States.ORCID 0000-0001-7450-3135
Emily MeversDepartment of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0001-7986-5610

Funding

Unlocking the biomedical potential of microbial symbionts from complex ecosystems; Admin Supplement for InstrumentationR35GM146740 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Emily Elizabeth Mevers · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM146740NIH HHS HHSN271201800023C
6 · The paper itself

Abstract

Millipedes have long been known to produce structurally diverse chemical defenses, including hydrogen cyanide, terpenoid alkaloids, and oxidized aromatics. Although the hydrogen cyanide and oxidized aromatic producing millipedes have been well studied, less than 10% of the terpenoid alkaloid producers have been chemically investigated. Several previous studies have shown that alkaloids disorient predators, but their biochemical target is currently unknown. Herein, we investigated the defensive secretions of a colobognath millipede,

Indexed as

AlkaloidsArthropodsAnimalsAntsMolecular StructureNeurotransmitter AgentsTerpenesAlkaloidsNeurotransmitter AgentsTerpenes

Identifiers

PMID39849940
PMCPMC11773556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.