Evidence map›Paper›PMID 39849639›Full record

ArticleJournal of cannabis research2025

Oral cannabidiol did not impair learning and memory in healthy adults.

Hanna H Gebregzi, Joanna S Zeiger, Jeffrey P Smith, Libby Stuyt, Luann Cullen, Jim Carsella, Daniel C Rogers, Jordan Lafebre, Jennah Knalfec, Alfredo Vargas and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cannabis research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06074172 (The Effect of Cannabidiol in Learning and Memory of Adults), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06074172 phase2completednot on this map

The Effect of Cannabidiol in Learning and Memory of Adults

TypeinterventionalSponsorColorado State UniversityRan2020 to 2020Enrolled57ConditionsMemoryArmsCannabidiol (246mg press pill), Placebo (246mg press pill)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hanna H GebregziDepartment of Biology, Colorado State University Pueblo, 2200 Bonforte Blvd, Pueblo, CO, 81001, USA.
Joanna S ZeigerCann Research Foundation, 3996 Savannah Ct, Boulder, CO, 80301, USA.
Jeffrey P SmithDepartment of Biology, Colorado State University Pueblo, 2200 Bonforte Blvd, Pueblo, CO, 81001, USA.
Libby StuytCircle Program, Colorado Mental Health Institute at Pueblo, 1600 W 24th Street, Pueblo, CO, 81003, USA.
Luann CullenCullen Regenerative Medicine, Naturopathic Medicine, 112 W D St, Pueblo, CO, 81003, USA.
Jim CarsellaCullen Regenerative Medicine, Naturopathic Medicine, 112 W D St, Pueblo, CO, 81003, USA.
Daniel C RogersDepartment of Biology, Colorado State University Pueblo, 2200 Bonforte Blvd, Pueblo, CO, 81001, USA.
Jordan LafebreDepartment of Biology, Colorado State University Pueblo, 2200 Bonforte Blvd, Pueblo, CO, 81001, USA.
Jennah KnalfecDepartment of Biology, Colorado State University Pueblo, 2200 Bonforte Blvd, Pueblo, CO, 81001, USA.
Alfredo VargasDepartment of Biology, Colorado State University Pueblo, 2200 Bonforte Blvd, Pueblo, CO, 81001, USA.
Moussa M DiawaraDepartment of Biology, Colorado State University Pueblo, 2200 Bonforte Blvd, Pueblo, CO, 81001, USA. moussa.diawara@csupueblo.edu.ORCID http://orcid.org/0009-0008-4099-785X

Funding

Institute of Cannabis Research Institute of Cannabis Research
6 · The paper itself

Abstract

backgroundThe effect of oral Cannabidiol (CBD) on interference during learning and memory (L&M) in healthy human volunteers has not been studied.

methodA two-arm crossover, randomized, double-blind, placebo-controlled trial was conducted at Colorado State University Pueblo (CSU Pueblo) to evaluate the effects of 246 mg oral CBD on L&M in healthy adults. Among 57 healthy volunteers enrolled, 35 were included in the analyses. For assessment of L&M, Montreal Cognitive Assessment (MOCA) was used to evaluate verbal baseline cognitive function; RAVLT-R tests (List A and List B recalls, Proactive and Retroactive Interference ratios, and Forgetting Speed ratio) were used to evaluate verbal declarative memory; and total prose recall was used to evaluate verbal logical memory. Linear Mixed Models with Bonferroni Corrections were used to compare L&M results between primary outcomes (CBD vs. placebo) and secondary demographic outcomes, with a two-tailed statistical significance of P < 0.05.

resultsCBD administration did not affect any of the dependent variables measured compared to the placebo group. There were no effects of THC, history of CBD use, or sex on CBD's modulation of L&M. However, a highly significant interaction effect between treatment groups (CBD vs. placebo) and age of subjects was observed for the PI ratio (P = 0.008; n = 35).

conclusionsThe results of this study suggest that administration of oral CBD alone does not significantly impair L&M in healthy adults. However, age might influence CBD related modulation of proactive interference during human L&M. Future research involving a larger group of older adults is needed to confirm this potential effect.

trial registrationThe study was approved by the CSU Pueblo IRB, conducted in accordance with the Declaration of Helsinki, and registered with ClinicalTrials.gov (NCT06074172).

Indexed as

CBDL&MLogical Memory SubtestMOCAPI ratioProse recallRAVLT-RRI ratioTHCWMS

Identifiers

PMID39849639
PMCPMC11756171

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.