Evidence map›Paper›PMID 39849583›Full record

ArticleStem cell research & therapy2025

Promoting epithelial regeneration in chemically induced acute lung injury through Sox9-positive alveolar type 2 epithelial cells.

Chao Cao, Obulkasim Memete, Yu Dun, Lin Zhang, Fuli Liu, Daikun He, Jian Zhou, Yiru Shao, Jie Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chao CaoCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, People's Republic of China.
Obulkasim MemeteCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, People's Republic of China.
Yu DunCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, People's Republic of China.
Lin ZhangCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, People's Republic of China.
Fuli LiuCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, People's Republic of China.
Daikun HeCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, People's Republic of China.
Jian ZhouDepartment of Pulmonary and Critical Care Medicine, Shanghai Respiratory Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yiru ShaoCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, People's Republic of China. shaoyiru1983@163.com.
Jie ShenCenter of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, People's Republic of China.ORCID http://orcid.org/0000-0001-5723-6186

Funding

China Postdoctoral Science Foundation 2024M762043National Natural Science Foundation of China 81902007National Natural Science Foundation of China 82002027National Natural Science Foundation of China 82272243Natural Science Foundation of Shanghai Municipality 24ZR1445800Tianjin Municipal Health Commission 2023221
6 · The paper itself

Abstract

backgroundChemical-induced acute lung injury is characterized by impaired epithelial regenerative capacity, leading to acute pulmonary edema. Numerous studies have investigated the therapeutic potential of endogenous stem cells with particular emphasis on alveolar type 2 epithelial (AEC2) cells owing to their involvement in lung cell renewal. Sox9, a transcription factor known for its role in maintaining stem cell properties and guiding cell differentiation, marks a subset of AEC2 cells believed to contribute to epithelial repair. However, the role of Sox9

methodsIn this study, we generated Sox9

resultsOur findings revealed that Sox9

conclusionThese results provide compelling in vivo genetic evidence supporting the characterization of Sox9

Indexed as

Acute Lung InjuryAlveolar Epithelial CellsRegenerationSOX9 Transcription FactorAnimalsCell DifferentiationCell ProliferationMiceSox9 protein, mouseSOX9 Transcription FactorAlveolar type 2 epithelial cellsCell differentiationChemically induced acute lung injuryEpithelial regenerationImmune regulationSox9

Identifiers

PMID39849583
PMCPMC11756119

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.