Evidence map›Paper›PMID 39849481›Full record

SynthesisBMC surgery2025

Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysis.

Motoi Uchino, Koji Tamura, Shinsuke Nomura, Seiichi Shinji, Keita Kouzu, Hiroji Shinkawa, Tomohiro Ishinuki, Toru Mizuguchi, Hiroki Ohge, Seiji Haji and 14 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Motoi UchinoDepartment of Gastroenterological Surgery, Division of Inflammatory Bowel Disease, Hyogo Medical University, 1-1, Mukogawacho, Nishinomiya, Hyogo, Japan. uchino2s@hyo-med.ac.jp.
Koji TamuraDepartment of Surgery and Oncology Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shinsuke NomuraDepartment of Surgery, Hayamizu-Park Clinic, Miyazaki, Japan.
Seiichi ShinjiDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Bunkyo, Japan.
Keita KouzuDepartment of Surgery, National Defence Medical College, Tokorozawa, Japan.
Hiroji ShinkawaDepartment of Hepatobiliary-Pancreatic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Tomohiro IshinukiDepartment of Nursing, Division of Surgical Science, Sapporo Medical University, Sapporo, Japan.
Toru MizuguchiDepartment of Nursing, Division of Surgical Science, Sapporo Medical University, Sapporo, Japan.
Hiroki OhgeDepartment of Infectious Disease, Hiroshima University Hospital, Hiroshima, Japan.
Seiji HajiDepartment of Surgery, Soseikai General Hospital, Kyoto, Japan.
Junzo ShimizuDepartment of Surgery, Toyonaka Municipal Hospital, Osaka, Japan.
Yasuhiko MohriDepartment of Gastrointestinal Surgery, Mie Prefectural General Medical Center, Mie, Japan.
Chizuru YamashitaDepartment of Anesthesiology and Critical Care Medicine, Fujita Health University, Toyoake, Aichi, Japan.
Yuichi KitagawaDepartment of Gastrointestinal Surgery, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Katsunori SuzukiDepartment of Infection Control, Hospital of the University of Occupational and Environmental Health, Fukuoka, Japan.
Motomu KobayashDepartment of Anesthesiology, Hokushinkai Megumino Hospital, Hokkaido, Japan.
Masahiro KobayashiDepartment of Clinical Pharmacokinetics, Research and Education Center for Clinical Pharmacy, Kitasato University Hospital, Sagamihara, Kanagawa, Japan.
Yuki HanaiDepartment of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University, Ota, Japan.
Hiroshi NobuharaDepartment of Dentistry, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Hiroki ImaokaDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie, Japan.
Masahiro YoshidaDepartment of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery, School of Medicine, International University of Health and Welfare, Otawara, Japan.
Toshihiko MayumiDepartment of Intensive Care Unit, Japan Community Healthcare Organization Chukyo Hospital, Nagoya, Japan.
Hiroki IkeuchiDepartment of Gastroenterological Surgery, Division of Inflammatory Bowel Disease, Hyogo Medical University, 1-1, Mukogawacho, Nishinomiya, Hyogo, Japan.
SSI Prevention Guideline Committee in Japan Society for Surgical Infection

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgical site infections (SSIs) can affect mortality, morbidity, and medical costs. Although it has recently been reported that washing with antiseptic/antibiotic solution can prevent SSI in clean surgery, the clinical impact in gastrointestinal surgery is still uncertain. Therefore, we performed a systematic review and meta-analysis to evaluate the efficacy of antiseptic/antibiotic solution during wound irrigation or peritoneal lavage in gastroenterological surgery.

methodsThe database search used PubMed, MEDLINE, and Cochrane Library. The following inclusion criteria were set for the systematic review. 1) Studies comparing with or without antiseptic/antibiotic irrigation/lavage during gastrointestinal surgery. 2) Studies that described surgical site infections and adverse events. 3) Studies conducted after 2000.

resultsA total of 8 randomized controlled studies (RCTs) and 3 observational studies were included in this meta-analysis. Three RCTs of wound irrigation with povidone iodine (PVI) solution revealed no significant difference between the PVI and control groups [RR 1.41, 95% CI (0.92 to 2.17): p = 0.69]. Three RCTs of peritoneal lavage with antibiotic solution showed no significant difference between the interventional group and control groups [RR 0.39, 95% CI (0.10 to 1.55): p = 0.18]. Regarding other antiseptic or antibiotic solutions, the number of studies and participants were too small for evaluation.

conclusionWound irrigation and peritoneal lavage with antiseptic/antibiotic solution did not have enough efficacy for preventing SSI during gastroenterological surgery.

Indexed as

Anti-Bacterial AgentsAnti-Infective Agents, LocalDigestive System Surgical ProceduresPeritoneal LavageSurgical Wound InfectionTherapeutic IrrigationHumansAnti-Bacterial AgentsAnti-Infective Agents, LocalAntiseptic/antibiotic solutionGastrointestinal surgeryMorbidityPeritoneal lavageSurgical site infectionsWound irrigation

Identifiers

PMID39849481
PMCPMC11755853

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.