ArticleBMC urology2025
The impact of absorbable hemostatic agents on wound healing in an experimental penile fracture rat model.
Article in BMC urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Preclinical Performance Evaluation of an Oxidized Regenerated Cellulose Hemostat: Antibacterial Activity and Wound Healing Outcomes.Medical devices (Auckland, N.Z.) · 2026Article
- Biological Macromolecule-Based Dressings for Combat Wounds: From Collagen to Growth Factors-A Review.Medical sciences (Basel, Switzerland) · 2025Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate the effects of two absorbable hemostatic agents, oxidized regenerated cellulose (ORC) and gelatin sponge, on wound healing in a rat model of penile fracture. MATERIALS AND
methodsA total of 32 Wistar albino rats were divided into four groups: Control (C), Primary Suturing (PS), ORC, and Gelatin Sponge (GS). A penile fracture model was created in all rats, and wound healing was assessed histopathologically after two weeks. Key parameters assessed included primary healing, fibrosis, inflammation, and cavernous tissue healing.
resultsThe ORC group showed significantly higher primary healing rates (100%) compared to the other groups (p < 0.01). Fibrosis was more common in the GS group (87.5%), whereas no fibrosis was observed in the ORC group (p < 0.01). In terms of cavernous tissue healing, the group treated with the ORC absorbable hemostatic agent demonstrated significantly higher healing rates compared to the control group (p = 0.000). No significant differences were observed between groups regarding inflammation.
conclusionORC absorbable hemostatic agents significantly promote primary wound healing and reduce fibrosis in an experimental penile fracture model, whereas the gelatin sponge was associated with increased fibrosis and did not improve healing. These findings suggest that ORC may have potential clinical applications in penile fracture repair. Further clinical studies are necessary to validate these results.
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