Evidence map›Paper›PMID 39849358›Full record

ArticleBMC infectious diseases2025

Genetic characterization of measles virus circulating in Iran, 2021-2023.

Alireza Esmaeiloghli Amiryli, Simin Abbasi, Faezeh Tarpoor, Azadeh Shadab, Azam Saboori, Nazanin-Zahra Shafiei Jandaghi, Vahid Salimi, Talat Mokhtari-Azad

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Alireza Esmaeiloghli AmiryliDepartment of Virology, School of Public Health, National Measles Laboratory (NML), Tehran University of Medical Sciences, Tehran, Iran.
Simin AbbasiDepartment of Virology, School of Public Health, National Measles Laboratory (NML), Tehran University of Medical Sciences, Tehran, Iran.
Faezeh TarpoorDepartment of Virology, School of Public Health, National Measles Laboratory (NML), Tehran University of Medical Sciences, Tehran, Iran.
Azadeh ShadabDepartment of Virology, School of Public Health, National Measles Laboratory (NML), Tehran University of Medical Sciences, Tehran, Iran.
Azam SabooriCentre for Communicable Diseases Control, Ministry of Health and Medical Education, Tehran, Iran.
Nazanin-Zahra Shafiei JandaghiDepartment of Virology, School of Public Health, National Measles Laboratory (NML), Tehran University of Medical Sciences, Tehran, Iran.
Vahid SalimiDepartment of Virology, School of Public Health, National Measles Laboratory (NML), Tehran University of Medical Sciences, Tehran, Iran.
Talat Mokhtari-AzadDepartment of Virology, School of Public Health, National Measles Laboratory (NML), Tehran University of Medical Sciences, Tehran, Iran. mokhtari@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMeasles, an ongoing public health concern, demands continuous molecular surveillance and virus characterization for elimination. Despite Iran achieving measles elimination status in 2019 through robust molecular testing and vaccination, the COVID-19 pandemic disrupted global vaccination efforts, leading to increased measles-related morbidity and mortality. This study aims to overview measles virus serological and molecular traits in Iran from 1st January 2021 to 30th April 2023.

methodsFollowing World Health Organization and Center for Diseases and Control protocols, serological tests were performed on suspected cases and the nucleoprotein (N) gene of confirmed cases were subsequently amplified using molecular methods and were sequenced afterwards for measles genotyping. Phylogenetic analysis was performed with the obtained sequences.

resultsAnalyzing 17,343 suspected cases from 1st January 2021 to 30th April 2023, 936, 177, and 164 samples were positive using ELISA, quantitative Reverse transcription PCR, and Reverse transcription PCR, respectively. The B3 genotype predominated, notably in Iran's South East (41%), Central (28%), and South (13%) regions. Provinces bordering countries with measles outbreaks exhibited higher risk of virus importation. Genetic comparisons with measles sequences submitted to NCBI and MeaNS databases revealed direct importation and contact transmission.

conclusionRegular surveillance and genetic analysis are critical for understanding measles transmission and reacting to outbreaks. The COVID-19 pandemic yielded mixed effects on measles cases, enhancing hygiene measures while causing underreporting and vaccination gaps. Vigilance against measles resurgence is crucial, requiring cross-border transmission studies, improving cross-border surveillance and adaptable vaccination strategies.

Indexed as

MeaslesMeasles virusAdolescentAdultChildChild, PreschoolCOVID-19FemaleGenotypeHumansInfantIranMaleNucleocapsid ProteinsPhylogenyYoung AdultNucleocapsid Proteinsnucleoprotein, Measles virusB3 genotypeCOVID-19Genotypic characterizationIranMeaslesMolecular surveillance

Identifiers

PMID39849358
PMCPMC11755830

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.