Evidence map›Paper›PMID 39849265›Full record

ArticleClinical oral investigations2025

Masquelet technique combined with concentrated growth factors for the reconstruction of rabbit mandibular marginal bone defect.

Lingling Chen, Tao Wang, Meifang Chen, Cheng Feng, Jianzhe Wang, Zhenyu Shi, Ye Wu

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Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Lingling Chen *Fujian Key Laboratory of Oral Diseases & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian Province, 350002, China.
Tao Wang *Fujian Key Laboratory of Oral Diseases & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian Province, 350002, China.
Meifang ChenFuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, 350002, China.
Cheng FengFujian Key Laboratory of Oral Diseases & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian Province, 350002, China.
Jianzhe WangFujian Key Laboratory of Oral Diseases & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian Province, 350002, China.
Zhenyu ShiFujian Key Laboratory of Oral Diseases & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian Province, 350002, China.
Ye WuFujian Key Laboratory of Oral Diseases & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian Province, 350002, China. wuye@fjmu.edu.cn.

Funding

Fujian Provincial Department of Finance 22SCZZX010Fujian Provincial Department of Science and Technology 2021J01805Fujian Provincial Health Technology Project 2020CXB031
6 · The paper itself

Abstract

objectiveBoth the Masquelet technique (MT) and concentrated growth factors (CGF) reduce early graft loss and improve bone regeneration. This study aims to explore the efficacy of combining MT with CGF for mandibular defect repair by characterizing the induced membrane and assessing in vivo osteogenesis. MATERIALS AND

methodsThree experimental groups were compared: negative control (NC), MT, and Masquelet combined with CGF (MTC). Four weeks after the first surgery, histopathology is used to identify the morphological structure of the induced membrane, evaluate the degree of vascularization, and the secretion levels of osteogenesis and angiogenesis-related growth factors. In vivo osteogenesis was assessed with a second autologous bone graft surgery 4 weeks later, and bone reconstruction was evaluated by micro-CT and histopathology.

resultsCGF significantly increased the induced membrane thickness, vascularization, and growth factor secretion levels. Quantitative micro-CT analysis showed that the bone volume fraction (BV/TV) at 4 weeks post-surgery was higher in the MTC group (23.30 ± 1.15%) compared to the MT group (16.50 ± 1.29%) and NC group (12.62 ± 1.23%) (P < 0.05). By 12 weeks, the difference in BV/TV between MTC (32.59 ± 0.11%) and MT (29.89 ± 0.49%) reduced, indicating consistent bone regeneration. Trabecular parameters were consistently higher in the MTC group, highlighting enhanced osteogenesis.

conclusionCombining the Masquelet technique with CGF effectively reduces early bone graft absorption and promotes bone repair. These findings suggest potential benefits for oral and maxillofacial bone defect treatment, though further studies are needed to confirm long-term efficacy. CLINICAL RELEVANCE: Integrating Masquelet technique and CGF in mandibular reconstruction may improve clinical outcomes by enhancing bone regeneration and reducing graft failure.

Indexed as

Bone RegenerationBone TransplantationIntercellular Signaling Peptides and ProteinsMandibleMandibular ReconstructionAnimalsMaleOsteogenesisRabbitsX-Ray MicrotomographyIntercellular Signaling Peptides and ProteinsConcentrated growth factorsInduced membrane techniqueMandibular defectsMasquelet technique

Identifiers

PMID39849265

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.