ArticleJapanese journal of radiology2025
Usefulness of four-dimensional noise reduction filtering using a similarity algorithm in low-dose dynamic computed tomography for the evaluation of breast cancer: a preliminary study.
Article in Japanese journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the effects of four-dimensional noise reduction filtering using a similarity algorithm (4D-SF) on the image quality and tumor visibility of low-dose dynamic computed tomography (CT) in evaluating breast cancer. MATERIALS AND
methodsThirty-four patients with 38 lesions who underwent low-dose dynamic breast CT and were pathologically diagnosed with breast cancer were enrolled. Dynamic CT images were reconstructed using iterative reconstruction alone or in combination with 4D-SF. We selected the peak enhancement phase image of breast cancer for each patient for quantitative and qualitative evaluations of image quality and measurement of the maximum diameter of breast cancer. The signal-to-noise and contrast-to-noise ratios were calculated for quantitative evaluation. The maximum diameters of the breast cancer were measured from the images obtained with and without 4D-SF (4D-SF ±) (size-4D-SF + and size-4D-SF-) and for the pathological specimen (size-PS) and compared.
resultsThe median and interquartile ranges of the signal-to-noise ratio [4D-SF-: 3.03 (2.54-4.17) vs 4D-SF + : 5.52 (4.75-6.66)] and contrast-to-noise ratio [4D-SF-: 2.88 (2.00-3.60) vs 4D-SF + : 7.84 (4.65-10.35)] were significantly higher for 4D-SF + than for 4D-SF- (p < 0.001). The overall image quality (Observer 1, p < 0.001; Observer 2, p < 0.001) and tumor margin sharpness scores (Observer 1, p = 0.003; Observer 2, p < 0.001) were significantly higher for 4D-SF + than for 4D-SF-. The tumor contrast scores for 4D-SF + and 4D-SF- were not significantly different (Observers 1, 2; p = 0.083). Size-4D-SF- was significantly smaller than size-PS (p < 0.001); size-4D-SF + was also smaller than size-PS, but the difference was not significant (p = 0.088). The Spearman's rank correlation coefficient was 0.65 for size-PS and size-4D-SF- and 0.77 for size-PS and size-4D-SF + .
conclusionThe 4D-SF can improve the image quality and tumor visibility of low-dose dynamic CT in evaluating breast cancer extent due to noise reduction.
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