Evidence map›Paper›PMID 39849207›Full record

ArticleJournal of molecular histology2025

Persimmon (Diospyros kaki L.) leaves accelerates skin tissue regeneration in excisional wound model: possible molecular mechanisms.

Talal Salem H Al-Qaisi, Ahmed A J Jabbar, Mohammed M Hussein M Raouf, Parween AbdulSamad Ismail, Ramzi A Mothana, Mohammed F Hawwal, Rawaz Rizgar Hassan, Mahmood Ameen Abdulla, Musher Ismael Saleh, Mohammed Awad

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Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Talal Salem H Al-QaisiDepartment of Biomedical Sciences, College of Health Sciences, Abu Dhabi University, P.O. Box 59911, Abu Dhabi, United Arab Emirates.
Ahmed A J JabbarDepartment of Medical Laboratory Technology, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, 44001, Iraq. ahmed.abuljabbar@epu.edu.iq.ORCID http://orcid.org/0000-0001-9689-4018
Mohammed M Hussein M RaoufDepartment of Biomedical Sciences, College of Applied Science, Cihan University-Erbil, Kurdistan Region, Erbil, 44001, Iraq.
Parween AbdulSamad IsmailDepartment of Chemistry, College of Education, Salahaddin University, Erbil, 44001, Iraq.
Ramzi A MothanaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Mohammed F HawwalDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Rawaz Rizgar HassanDepartment of Medical microbiology, College of Science, Knowledge University, Kirkuk Road, Erbil, 44001, Iraq.
Mahmood Ameen AbdullaDepartment of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil, Iraq.
Musher Ismael SalehDepartment of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region, Erbil, 44001, Iraq.
Mohammed AwadDepartment of Chemical Engineering, Toronto Metropolitan University, Toronto, ON, Canada.

Funding

The Research was funded by the Researchers Supporting Project program (RSP2024R884), King Saud University, Riyadh, Saudi Arabia RSP2024R884
6 · The paper itself

Abstract

Persimmon (Diospyros kaki L.) leaves are a traditional medicinal herb used for treating many infectious and inflammatory-related conditions, including wound healing. To validate its traditional use, our study evaluates the acute toxicity and wound-healing effects of methanolic extracts of Persimmon (Diospyros kaki L.) leaves (MEPL) on excisional neck injury in rats. A uniform dorsal neck injury was created for twenty-four Sprague Dawley rats, which were randomly aligned into 4 groups and treated topically twice daily with 0.2 ml of the following: group A, rats treated with 1% CMC; group B, rats received intrasite gel; groups C and D, rats treated with MEPL (0.2 ml of 250 and 500 mg/kg, respectively). The toxicity results showed a lack of physiologic alteration or mortality in rats ingested with an oral dosage of up to 5 g/kg of MEPL. Histological screening of regenerated skin tissues revealed higher deposition of collagen, fibroblast cells, and reduced inflammatory cells in MEPL-treated rats. The topical application of MEPL led to positive modulation of Transforming Growth Factor Beta 1 (angiogenetic factor) in wound tissues, indicating increased tissue regeneration and faster wound contraction. MEPL treatment caused a significant elevation of tissue antioxidants (superoxide dismutase and catalase) and hydroxyproline (collagen) contents while reducing malondialdehyde contents. The inflammatory mediators (TNF-α and IL-6) were lower, and anti-inflammatory cytokines (interleukin 10) were higher in MEPL-treated rats than in the vehicle group. The study outcomes back up the traditional use of MEPL for wound healing, which could be linked with its phytochemicals (flavonoids and terpenoids) that require further isolation and molecular identification.

Indexed as

DiospyrosPlant ExtractsPlant LeavesRegenerationSkinWound HealingAnimalsDisease Models, AnimalMaleRatsRats, Sprague-DawleyPlant ExtractsAntioxidantsDiospyros kaki L.ImmunohistochemicalInflammatory cytokinesWound healing

Identifiers

PMID39849207

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.