Evidence map›Paper›PMID 39849107›Full record

ArticlePediatric cardiology2026

Prenatal Diagnosis of Congenital Heart Disease in Liveborn Infants in the New England Region.

Caitlin S Haxel, Alicia Wang, Jami C Levine, Nancy Drucker, Michael R Hart, Jenifer A Glatz, Dina Ferdman, Ruchika Karnik, Anna Tsirka, Puneeta Arya and 4 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Caitlin S HaxelDivision of Pediatric Cardiology, Department of Pediatrics, University of Vermont Children's Hospital, Larner College of Medicine at The University of Vermont, 111 Colchester Avenue, Burlington, VT, 05401, USA. caitlin.haxel@uvmhealth.org.
Alicia WangDivision of Pediatric Cardiology, Department of Pediatrics, Connecticut Children's Medical Center, University of Connecticut School of Medicine, Hartford, CT, USA.
Jami C LevineDepartment of Cardiology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Nancy DruckerDivision of Pediatric Cardiology, Department of Pediatrics, University of Vermont Children's Hospital, Larner College of Medicine at The University of Vermont, 111 Colchester Avenue, Burlington, VT, 05401, USA.
Michael R HartDivision of Pediatric Cardiology, Department of Pediatrics, Maine Medical Center, Portland, ME, USA.
Jenifer A GlatzDivision of Pediatric Cardiology, Department of Pediatrics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Dina FerdmanSection of Pediatric Cardiology, Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Ruchika KarnikSection of Pediatric Cardiology, Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Anna TsirkaDivision of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA, USA.
Puneeta AryaDivision of Pediatric Cardiology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Meaghan DohertyDivision of Pediatric Cardiology, Department of Pediatrics, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Kristin LarajaDivision of Pediatric Cardiology, Department of Pediatrics, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Sean HagenbuchPediatric Cardiology, Northern Light Eastern Maine Medical Center, Bangor, ME, USA.
Kathleen M RotondoDivision of Pediatric Cardiology, Department of Pediatrics, Hasbro Children's Hospital, The Warren Alpert Medical School at Brown University, Providence, RI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prenatal diagnosis of congenital heart disease requiring early cardiac catheterization or surgical intervention enables optimal delivery planning for appropriate postnatal cardiovascular intervention and care. This allows for improved morbidity and mortality. Prior national data reported prenatal diagnosis rates of 32% for congenital heart disease requiring intervention in infants in the first 6 months of life in the New England region. With improved technology, access to care and changes to the obstetrical ultrasound guidelines for mid trimester fetal study, it is expected that diagnostic rates should improve. The New England Congenital Cardiology Association (NECCA) conducted a quality improvement study to determine the rates of prenatal detection in the current era with the hypothesis that there has been improvement in detection rates in this region. Ten of fourteen medical centers delivering pediatric cardiology care in New England contributed prenatal diagnosis data for 286 infants born at the participating centers during a one year period. The overall prenatal detection rate was 68%. Detection rates ranged from 39 to 90%. When fetal echocardiogram was performed at a pediatric cardiology center, the detection rate was 95% with only 7 moderate (7/195; 3.6%) and 3 severe (3/195; 1.5%) diagnostic discrepancies. Prenatal diagnostic rate and accuracy are high among pediatric cardiology centers in the New England region, and much improved over historical data. To improve fetal detection of congenital heart disease further, future work is needed to better determine the etiology of missed prenatal diagnoses and efforts should be focused on increasing appropriate referrals to pediatric cardiology centers for fetal evaluation.

Indexed as

Heart Defects, CongenitalPrenatal DiagnosisUltrasonography, PrenatalEchocardiographyFemaleHumansInfant, NewbornNew EnglandPregnancyQuality ImprovementCongenital heart diseaseFetal cardiologyNew England regionPrenatal diagnosis

Identifiers

PMID39849107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.