Evidence map›Paper›PMID 39849102›Full record

ArticleAesthetic plastic surgery2025

A Combined Treatment Proposal for the Empty Deep Pyriform Space.

Helena Hotz Arroyo Ramos, Virginia Marcia Amaral, Luanda Pinheiro de Oliveira Afonso, Michelle Giovanella, Maxrose Ferreira Moura Freitas, Valcilene Alves de Freitas Lima, Viviane Bruno Schmidt, Guilherme Muzy

Abstract read
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In one paragraph

Article in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Helena Hotz Arroyo RamosInstituto Lapidare, Balneario Camboriu, SC, Brazil. helenaharroyo@hotmail.com.ORCID 0000-0002-1661-4993
Virginia Marcia AmaralInstituto Lapidare, Balneario Camboriu, SC, Brazil.
Luanda Pinheiro de Oliveira Afonso, Brasilia, Brazil.
Michelle Giovanella, Curitiba, Brazil.
Maxrose Ferreira Moura Freitas, Coremas, Brazil.
Valcilene Alves de Freitas Lima, João Pessoa, Brazil.
Viviane Bruno Schmidt, Rio de Janeiro, Brazil.
Guilherme Muzy, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeepening of the nasolabial fold (NLF), drooping of the nasal tip, and facial expressions perceived as angry face, are common esthetic concerns. However, no studies have correlated this set of signs and symptoms with common anatomical causes. We review anatomical considerations of the region and propose a combined treatment modality.

methodsWe performed a retrospective analysis of cases treated with combined botulinum toxin (abobotulinumtoxinA) using an injection pattern encompassing the nasal muscles and hyaluronic acid (HA) fillers in the deep pyriform space. Photographs were taken at rest and during motion (frontal and oblique views), before and after treatment.

resultsResults demonstrated effacement of the NLF, improved nasal tip positioning during smiling, and generally more favorable facial expressions.

conclusionsCombined treatment with HA in the deep pyriform space and abobotulinumtoxinA in the nasal muscles can improve angry expression and aging stigma in patients with deep empty pyriform space, both in the static and dynamic conditions of facial mimic. LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Botulinum Toxins, Type ACosmetic TechniquesDermal FillersHyaluronic AcidNasolabial FoldSkin AgingAdultCohort StudiesCombined Modality TherapyEstheticsFacial ExpressionFacial MusclesFemaleFollow-Up StudiesHumansMaleBotulinum Toxins, Type ADermal FillersHyaluronic AcidBotulinum toxinDynamic wrinklesFacial expression of disgustNasal drooping tipNasolabial foldPyriform space

Identifiers

PMID39849102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.