ArticleScientific reports2025
Clinical utility of hematological parameters in aplastic anemia.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Distinguishing causal from tagging enhancers using single-cell multiome data.medRxiv : the preprint server for health sciences · 2026Article
- Incidence trends of aplastic anaemia in Kazakhstan: a nationwide study (2014-2024).Frontiers in medicine · 2026Article
- Association between serum platelet level and dermatitis rash: Results from the China Health and Nutrition Survey.PloS one · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematological parameters available on automated hematology analyzers have been shown to be useful indicators for hematological disorders. However, extensive studies especially in aplastic anemia for these indices are sparse. Our aim was to investigate the clinical utility of hematological parameters in aplastic anemia. The retrospective study included 146 patients with aplastic anemia and 150 normal controls matched in age and gender, where clinical characteristics and hematological parameters were classified and statistically analyzed. The study showed a statistical difference in the hematological parameters between aplastic anemia patients and controls. White blood cells, absolute neutrophil count, platelet, absolute reticulocyte count, mean reticulocyte volume, immature reticulocyte fraction, mean sphered cell volume, and light scattering reticulocyte count showed significant differences between non-severe aplastic anemia and severe aplastic anemia (p < 0.05). The analysis of the ROC curve showed that the hematological parameters were valuable for the differential diagnosis of severe aplastic anemia (areas under curve of white blood cell, absolute neutrophil count, platelet, absolute reticulocyte count, mean reticulocyte volume, immature reticulocyte fraction, mean sphered cell volume, light scatter reticulocytes were 0.620-0.859). Meanwhile, a combination of absolute neutrophil count, absolute reticulocyte count and mean sphered cell volume (AUC 0.893, 95% confidence interval 0.842-0.943, sensitivity 78.9%, specificity 85.7%) showed excellent precision for the differential diagnosis of severe aplastic anemia. Hematological parameters are readily available parameters that can be helpful to differentiate severe aplastic anemia from non-severe aplastic anemia. They may extend valuable prospects for clinical practice and research in aplastic anemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.