ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025
Ionized calcium and PTH as predictors of hypoparathyroidism following total thyroidectomy.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Early Detection of Transient Hypoparathyroidism After Total Thyroidectomy: A Single-Center Preliminary Study.Medicina (Kaunas, Lithuania) · 2026Article
- Prediction of early postoperative hypocalcemia and hypoparathyroidism after thyroidectomy for papillary thyroid carcinoma: dual-outcome prediction models.Frontiers in endocrinology · 2026Article
- Predicting Hypocalcemia and Identifying Supplementation Needs After Total Thyroidectomy: The Role of Perioperative PTH Measurements.Biomedicines · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePost-surgical hypoparathyroidism (POSH) is a common complication after total thyroidectomy. This study aims to assess the accuracy of serum and ionized calcium and PTH levels on the first postoperative day (POD-1) to predict postoperative hypocalcemia (PoHC), transient hypoparathyroidism (THPT), and permanent hypoparathyroidism (PtHPT).
methodsBiochemical parameters and clinical variables were retrospectively analyzed in 200 patients. The optimal cut-off points were determined using ROC curve analysis. Results were correlated with analytical and clinical variables and patient outcomes.
resultsPoHC incidence in POD-1 was 46%; THPT and PtHPT were 37 and 9%, respectively. Ionized calcium < 4.43 mg/dL on POD-1 predicted PoHC (AUC = 0.9) better than PTH and serum calcium. PTH < 8.06 pg/mL on POD-1 predicted PtHPT (AUC = 0.797). Multivariate analysis identified PTH < 21.2 pg/mL, ionized calcium < 4.43 mg/dL, and serum calcium < 8.76 mg/dL on POD-1 as significant PoHC risk factors.
conclusionIonized calcium on POD-1 predicts PoHC accurately, while serum PTH indicates higher risk for PtHPT.
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