ArticleHypertension research : official journal of the Japanese Society of Hypertension2025
Investigating the association between human brainstem microstructural integrity and hypertension using magnetic resonance relaxometry.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Microstructural damage and lower myelin content in the Brainstem associated with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
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13 authors.
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Abstract
The brainstem plays a vital role in regulating blood pressure, and disruptions to its neural pathways have been linked to hypertension. However, it remains unclear whether subtle microstructural changes in the brainstem are associated with an individual's blood pressure status. This exploratory, cross-sectional study investigated the relationship between brainstem microstructure, myelination, and hypertensive status in 116 cognitively unimpaired adults (aged 22-94 years). Advanced MRI techniques, including relaxometry (R1, R2) and myelin water fraction (MWF) analysis, were employed to assess microstructural integrity and myelin content in ten brainstem subregions. Our results revealed significant associations between higher microstructural damage or lower myelin content (indicated by lower R1, R2, or MWF values) and hypertensive status, particularly in the midbrain tegmentum. Notably, combining these MRI metrics yielded high classification accuracy (AUC > 0.85). Our findings suggest a potential link between disrupted brainstem tissue integrity, myelin content, and elevated blood pressure, warranting further longitudinal investigations to explore this relationship.
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