Evidence map›Paper›PMID 39848944›Full record

ArticleBone research2025

Skeletal abnormalities caused by a Connexin43

Yasuyuki Fujii, Iichiro Okabe, Ayano Hatori, Shyam Kishor Sah, Jitendra Kanaujiya, Melanie Fisher, Rachael Norris, Mark Terasaki, Ernst J Reichenberger, I-Ping Chen

Abstract read
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In one paragraph

Article in Bone research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Yasuyuki Fujii *Department of Endodontology, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA.
Iichiro Okabe *Department of Endodontology, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA.
Ayano HatoriDepartment of Endodontology, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA.
Shyam Kishor SahDepartment of Endodontology, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA.
Jitendra KanaujiyaDepartment of Cell Biology, University of Connecticut Health, Farmington, CT, USA.
Melanie FisherDepartment of Cell Biology, University of Connecticut Health, Farmington, CT, USA.
Rachael NorrisDepartment of Cell Biology, University of Connecticut Health, Farmington, CT, USA.
Mark TerasakiDepartment of Cell Biology, University of Connecticut Health, Farmington, CT, USA.
Ernst J ReichenbergerCenter for Regenerative Medicine and Skeletal Development, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA.
I-Ping ChenDepartment of Endodontology, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA. ipchen@uchc.edu.ORCID http://orcid.org/0000-0002-7349-3091

Funding

Pathogenic Mechanisms of Craniometaphyseal DysplasiaR01DE025664 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI I-Ping Chen · 2016 to 2026
$4.5M
NIDCR NIH HHS R01 DE025664U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) DE025664
6 · The paper itself

Abstract

Craniometaphyseal dysplasia (CMD), a rare craniotubular disorder, occurs in an autosomal dominant (AD) or autosomal recessive (AR) form. CMD is characterized by hyperostosis of craniofacial bones and metaphyseal flaring of long bones. Many patients with CMD suffer from neurological symptoms. The pathogenesis of CMD is not fully understood. Treatment is limited to craniofacial surgery. Here, we report a knock in (KI) mouse model for AR CMD carrying a Cx43

Indexed as

Bone and BonesBone Diseases, DevelopmentalConnexin 43Craniofacial AbnormalitiesGenes, RecessiveHypertelorismMutationAnimalsDisease Models, AnimalFemaleMaleMiceOsteoclastsConnexin 43GJA1 protein, mouse

Identifiers

PMID39848944
PMCPMC11757998

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.