Evidence map›Paper›PMID 39848779›Full record

ArticleAJNR. American journal of neuroradiology2025

Advanced Distance-Resolved Evaluation of the Perienhancing Tumor Areas with FLAIR Hyperintensity Indicates Different ADC Profiles by

Gergely Bertalan, Nicolin Hainc, Fabian Dominik Von Dehn, Tibor Hortobágyi, Andrea Bink, Emilie Le Rhun, Michael Weller, Zsolt Kulcsar

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gergely BertalanFrom the Department of Neuroradiology (G.B., N.H., F.D.v.D., A.B., Z.K.), University Hospital Zürich, Zürich, Switzerland gergely.bertalan@usz.ch.
Nicolin HaincFrom the Department of Neuroradiology (G.B., N.H., F.D.v.D., A.B., Z.K.), University Hospital Zürich, Zürich, Switzerland.ORCID 0000-0003-0916-7387
Fabian Dominik Von DehnFrom the Department of Neuroradiology (G.B., N.H., F.D.v.D., A.B., Z.K.), University Hospital Zürich, Zürich, Switzerland.
Tibor HortobágyiInstitute of Neuropathology (T.H.), University Hospital Zürich, Zürich, Switzerland.ORCID 0000-0001-5732-7942
Andrea BinkFrom the Department of Neuroradiology (G.B., N.H., F.D.v.D., A.B., Z.K.), University Hospital Zürich, Zürich, Switzerland.ORCID 0000-0002-2163-3400
Emilie Le RhunDepartment of Neurology (E.L.R., M.W.), University Hospital Zürich, Zürich, Switzerland.
Michael WellerDepartment of Neurology (E.L.R., M.W.), University Hospital Zürich, Zürich, Switzerland.
Zsolt KulcsarFrom the Department of Neuroradiology (G.B., N.H., F.D.v.D., A.B., Z.K.), University Hospital Zürich, Zürich, Switzerland.ORCID 0000-0002-6805-5150

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeWhether differences in the O MATERIALS AND

methodsOne hundred one patients with

resultsFor both mMGMT and uMGMT GBM, mean ADC values around the tumor core significantly increased as a function of distance from the core toward the periphery of the perienhancing FLAIR hyperintensity (approximately 10% increase within 5 voxels with

conclusionsDistance-resolved volumetric ADC analysis around the tumor core reveals tissue signatures of GBM imperceptible to the human eye on conventional MRI. The different ADC profiles around the core suggest epigenetically influenced differences in perienhancing tissue characteristics between mMGMT and uMGMT GBM.

Indexed as

Brain NeoplasmsDNA MethylationDNA Modification MethylasesDNA Repair EnzymesGlioblastomaMagnetic Resonance ImagingTumor Suppressor ProteinsAdultAgedFemaleHumansImaging, Three-DimensionalMaleMiddle AgedPromoter Regions, GeneticRetrospective StudiesDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanTumor Suppressor Proteins

Identifiers

PMID39848779
PMCPMC11878967

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.