Evidence map›Paper›PMID 39848764›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

PET Quantification in Healthy Humans of Cyclooxygenase-2, a Potential Biomarker of Neuroinflammation.

Xuefeng Yan, Martin Noergaard, Cheryl L Morse, Jeih-San Liow, Jinsoo Hong, Douglas Greve, Sanjay Telu, Min-Jeong Kim, Jose A Montero Santamaria, Anthony Galassi and 13 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A comprehensive review ofMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. RadiolabeledFrontiers in nuclear medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Xuefeng YanIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Martin NoergaardIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Cheryl L MorseIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Jeih-San LiowIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Jinsoo HongIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Douglas GreveLaboratory for Computational Neuroimaging, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts.
Sanjay TeluIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Min-Jeong KimIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Jose A Montero SantamariaIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Anthony GalassiIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Ningping FengIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Sarah K Williams AvramIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Ted B UsdinIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Shawn WuIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Andrea ZhangIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Lester S ManlyIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Madeline JenkinsIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Maia Van BuskirkIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Adrian LeeIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Sami S ZoghbiIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Victor W PikeIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Paolo Zanotti-FregonaraIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Robert B InnisIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland; robert.innis@nih.gov.

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Clinical Evaluation of PET RadiotracersZIAMH002852 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$48.6M
Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002852
6 · The paper itself

Abstract

Cyclooxygenase-2 (COX-2) is present in a healthy brain at low densities but can be markedly upregulated by excitatory input and by inflammogens. This study evaluated the sensitivity of the PET radioligand [

Indexed as

Cyclooxygenase 2Neuroinflammatory DiseasesPositron-Emission TomographyAdultAnimalsBiomarkersBrainCelecoxibFemaleHealthy VolunteersHumansMaleMiceMice, TransgenicMiddle AgedRatsBiomarkersCelecoxibCyclooxygenase 2COX-2human brainneuroinflammationPET

Identifiers

PMID39848764
PMCPMC11876736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.