Evidence map›Paper›PMID 39848694›Full record

ArticleSexually transmitted infections2025

Diagnostic performance of

Tadesse Lejisa, Demiraw Bikila, Chala Bashea, Yosef Tolcha, Mehari Meles, Tigist Getahun, Genet Ashebir, Wossene Habtu, Feyissa Challa, Daniel Melese Desalegn and 3 more

Abstract readMulticenter StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Sexually transmitted infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tadesse LejisaNational Laboratories Capacity Building Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia hsr582005@gmail.com.ORCID 0000-0003-0382-5000
Demiraw BikilaNational Laboratories Capacity Building Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Chala BasheaNational Laboratories Capacity Building Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Yosef TolchaNational Laboratories Capacity Building Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Mehari MelesNational Laboratories Capacity Building Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Tigist GetahunNational Laboratories Capacity Building Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Genet AshebirNational Laboratories Capacity Building Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Wossene HabtuNational Laboratories Capacity Building Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Feyissa ChallaNational Laboratories Capacity Building Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Daniel Melese DesalegnNational Laboratories Capacity Building Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Adisu Kebede AnbessaAfrican Society for Laboratory Medicine, Addis Ababa, Ethiopia.
Gonfa AyanaNational Laboratories Capacity Building Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Habteyes Hailu TolaDepartment of Public Health, College of Health Sciences, Salale University, Fiche, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAlthough the burden of syphilis is slightly increasing worldwide, there are a limited number of rapid, simple-to-use, accurate and cost-effective diagnostic tools available. Thus, we aimed to determine the diagnostic performance of the

methodsWe conducted a multicentre cross-sectional study to evaluate the diagnostic performance of the index test against the reference test. We enrolled 581 syphilis-suspected cases from the five selected health facilities in Addis Ababa in this study. We collected data on sociodemographic and clinical characteristics and whole blood from each participant. We estimated the sensitivity, specificity and positive and negative predictive values of the index test.

resultsOf the 581 participants, 380 (65.4%) were female. The mean age of the participants was 39.7 years (±SD 16.6), with an age range of 18-94 years. The sensitivity of the index test was 99.4% (95% CI 96.4% to 100%), while the specificity was 100%. The positive predictive value of the index test was 100%, and the negative predictive value was 99.8% (95% CI 98.4% to 100%). There was no invalid test result.

conclusionsThe diagnostic performance of TPPA for syphilis was equivalent to that of ECLIA. Thus, TPPA can be used for the diagnosis of syphilis at the health facility level equivalent to a reference test.

Indexed as

Agglutination TestsAntibodies, BacterialSyphilisSyphilis SerodiagnosisTreponema pallidumAdolescentAdultAgedAged, 80 and overCross-Sectional StudiesEthiopiaFemaleHumansImmunoassayLuminescent MeasurementsMaleAntibodies, BacterialBacterial InfectionsClinical Laboratory TechniquesCommunicable DiseasesINFECTIOUS DISEASESSYPHILIS

Identifiers

PMID39848694
PMCPMC12322400

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.