Evidence map›Paper›PMID 39848427›Full record

Trial reportResuscitation2025

Practice patterns for acquiring neuroimaging after pediatric in-hospital cardiac arrest.

Matthew P Kirschen, Natalie L Ullman, Ron W Reeder, Tageldin Ahmed, Michael J Bell, Robert A Berg, Candice Burns, Joseph A Carcillo, Todd C Carpenter, J Wesley Diddle and 29 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Resuscitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02837497 (Improving Outcomes After Pediatric Cardiac Arrest), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02837497 nacompletednot on this map

Improving Outcomes After Pediatric Cardiac Arrest

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2016 to 2021Enrolled1,127ConditionsCardiac ArrestArmsICU-RESUS CPR Improvement Bundle
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Matthew P KirschenDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA. Electronic address: kirschenm@chop.edu.
Natalie L UllmanDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA.
Ron W ReederDepartment of Pediatrics, University of Utah Salt Lake City UT USA.
Tageldin AhmedDepartment of Pediatrics, Children's Hospital of Michigan, Central Michigan University Detroit MI USA.
Michael J BellDepartment of Pediatrics, Children's National Hospital, George Washington University School of Medicine Washington DC USA.
Robert A BergDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA.
Candice BurnsDepartment of Pediatrics and Human Development, Michigan State University Grand Rapids MI USA.
Joseph A CarcilloDepartment of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh University of Pittsburgh Pittsburgh PA USA.
Todd C CarpenterDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado Aurora CO USA.
J Wesley DiddleDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA.
Myke FedermanDepartment of Pediatrics, Mattel Children's Hospital, University of California Los Angeles Los Angeles CA USA.
Ericka L FinkDepartment of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh University of Pittsburgh Pittsburgh PA USA.
Aisha H FrazierDepartment of Pediatrics, Nemours Children's Hospital, Delaware Wilmington DE USA.
Stuart H FriessDepartment of Pediatrics, Washington University School of Medicine St. Louis MO USA.
Kathryn GrahamDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA.
Christopher M HorvatDepartment of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh University of Pittsburgh Pittsburgh PA USA.
Leanna L HuardDepartment of Pediatrics, Mattel Children's Hospital, University of California Los Angeles Los Angeles CA USA.
Todd J KilbaughDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA.
Tensing MaaDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University Columbus OH USA.
Arushi MangaDepartment of Pediatrics, Washington University School of Medicine St. Louis MO USA.
Patrick S McQuillenDepartment of Pediatrics, Benioff Children's Hospital, University of California San Francisco San Francisco CA USA.
Kathleen L MeertDepartment of Pediatrics, Children's Hospital of Michigan, Central Michigan University Detroit MI USA.
Ryan W MorganDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA.
Peter M MouraniDepartment of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Little Rock AR USA.
Vinay M NadkarniDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA.
Maryam Y NaimDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA.
Daniel NottermanDepartment of Molecular Biology Princeton University Princeton NJ USA.
Chella A PalmerDepartment of Pediatrics, University of Utah Salt Lake City UT USA.
Murray M PollackDepartment of Pediatrics, Children's National Hospital, George Washington University School of Medicine Washington DC USA.
Anil SapruDepartment of Pediatrics, Mattel Children's Hospital, University of California Los Angeles Los Angeles CA USA.
Matthew P SharronDepartment of Pediatrics, Children's National Hospital, George Washington University School of Medicine Washington DC USA.
Neeraj SrivastavaDepartment of Pediatrics, Mattel Children's Hospital, University of California Los Angeles Los Angeles CA USA.
Bradley TilfordDepartment of Pediatrics, Children's Hospital of Michigan, Central Michigan University Detroit MI USA.
Shirley ViteriDepartment of Pediatrics, Nemours Children's Hospital, Delaware Wilmington DE USA.
Heather A WolfeDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA.
Andrew R YatesDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University Columbus OH USA.
Alexis TopjianDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA.
Robert M SuttonDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA.
Craig A PressDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia University of Pennsylvania Philadelphia PA USA.

Funding

Data Coordinating Center for the Collaborative Pediatric Critical Care Research NetworkU01HD049934 · NICHD · UNIVERSITY OF UTAH · PI DEAN, JONATHAN MICHAEL · 2005 to 2020
$35.2M
CPCCRN PRECISE SupplementPL1HD105462 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Kevin M Watt · 2021 to 2026
$17.5M
Improving Outcomes after Pediatric Cardiac ArrestR01HL131544 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI SUTTON, ROBERT MICHAEL · 2016 to 2020
$3.9M
Collaborative Pediatric Critical Care Research Network (CPCCRN) at Children's NationalUG1HD049981 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI POLLACK, MURRAY MICHAEL, WESSEL, DAVID LLOYD · 2015 to 2020
$1.8M
Pediatric Critical Care Research Network at Children's Hospital of PhiladelphiaUG1HD063108 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN, ZUPPA, ATHENA F. · 2015 to 2020
$1.7M
Collaborative Research to Validate Biomarkers of Pediatric ARDSUG1HD083166 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCQUILLEN, PATRICK SEAN, SAPRU, ANIL · 2015 to 2020
$1.6M
Renewal Application for the Childrens Hospital of Pittsburgh Collaborative Pediatric Critical Care Research Network SiteUG1HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2015 to 2020
$1.6M
Collaborative Pediatric Critical Care Research NetworkUG1HD050096 · NICHD · WAYNE STATE UNIVERSITY · PI MEERT, KATHLEEN L. · 2015 to 2020
$1.6M
Collaborative Network Study of Airway Microbiome and Host Responses in Pediatric Respiratory FailureUG1HD083171 · NICHD · UNIVERSITY OF COLORADO DENVER · PI CARPENTER, TODD C · 2015 to 2020
$1.5M
Collaborative Pediatric Critical Care Research Network (UG1)UG1HD083170 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI HALL, MARK W · 2015 to 2020
$1.5M
Cerebral autoregulation and MRI measures of brain injury after pediatric-post cardiac arrestK23NS116120 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI KIRSCHEN, MATTHEW P · 2021 to 2025
$966k
Pulmonary Hypertension-Associated Pediatric Cardiac ArrestK23HL148541 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI MORGAN, RYAN WILLIAM · 2020 to 2024
$791k
NHLBI NIH HHS K23 HL148541NHLBI NIH HHS R01 HL131544NICHD NIH HHS PL1 HD105462NICHD NIH HHS U01 HD049934NICHD NIH HHS UG1 HD049981NICHD NIH HHS UG1 HD049983NICHD NIH HHS UG1 HD050096NICHD NIH HHS UG1 HD063108NICHD NIH HHS UG1 HD083166NICHD NIH HHS UG1 HD083170NICHD NIH HHS UG1 HD083171NINDS NIH HHS K23 NS116120
6 · The paper itself

Abstract

aimsTo determine which patient and cardiac arrest factors were associated with obtaining neuroimaging after in-hospital cardiac arrest, and among those patients who had neuroimaging, factors associated with which neuroimaging modality was obtained.

methodsRetrospective cohort study of patients who survived in-hospital cardiac arrest (IHCA) and were enrolled in the ICU-RESUS trial (NCT02837497).

resultsWe tabulated ultrasound (US), CT, and MRI frequency within 7 days following IHCA and identified patient and cardiac arrest factors associated with neuroimaging modalities utilized. Multivariable models determined which factors were associated with obtaining neuroimaging. Of 1000 patients, 44% had ≥ 1 neuroimaging study (US in 31%, CT in 18%, and MRI in 6% of patients). Initial USs were performed a median of 0.3 [0.1,0.5], CTs 1.4 [0.4,2.8], and MRIs 4.1 [2.2,5.1] days post-arrest. Neuroimaging timing and frequency varied by site. Factors associated with greater odds of neuroimaging were cardiac arrest in CICU (versus PICU), longer duration CPR, receiving ECMO post-arrest, and post-arrest care with targeted temperature management or EEG monitoring. US performance was associated with congenital heart disease. CT was associated with age ≥ 1-month, greater pre-arrest disability, and receiving CPR for ≥ 16 min. MRI utilization increased with pre-existing respiratory insufficiency and respiratory decompensation as arrest cause, and medical cardiac and surgical non-cardiac or trauma illness category. Overall, if neuroimaging was obtained, US was more common in CICU while CT/MRI were utilized more in PICU.

conclusionsPractice patterns for acquiring neuroimaging after IHCA are variable and influenced by patient, cardiac arrest, and site factors.

Indexed as

Heart ArrestNeuroimagingPractice Patterns, Physicians'AdolescentCardiopulmonary ResuscitationChildChild, PreschoolFemaleHumansInfantMagnetic Resonance ImagingMaleRetrospective StudiesTomography, X-Ray ComputedUltrasonographyCardiac arrestCTMRINeuroimagingPediatric ICUUltrasound

Identifiers

PMID39848427
PMCPMC11842214

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Registered trials

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