Evidence map›Paper›PMID 39848200›Full record

ArticleCancer epidemiology2025

Risk of carcinomas among children and adolescents with birth defects.

Jeremy M Schraw, Ji Yun Tark, Tania A Desrosiers, Tiffany M Chambers, Charles J Shumate, Wendy N Nembhard, Mahsa M Yazdy, Eirini Nestoridi, Mary Frances Wedekind Malone, Theodore W Laetsch and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A Population-Based Assessment of Cancer Risk in Children With VACTERL.American journal of medical genetics. Part A · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jeremy M SchrawDivision of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX USA. Electronic address: jeremy.schraw@bcm.edu.
Ji Yun TarkSection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Tania A DesrosiersDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tiffany M ChambersDivision of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX USA.
Charles J ShumateBirth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, USA.
Wendy N NembhardDepartment of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Mahsa M YazdyDivision for Surveillance, Research, and Promotion of Perinatal Health, Massachusetts Department of Public Health, Boston, MA, USA.
Eirini NestoridiDivision for Surveillance, Research, and Promotion of Perinatal Health, Massachusetts Department of Public Health, Boston, MA, USA.
Mary Frances Wedekind MalonePediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Theodore W LaetschDepartment of Pediatrics, Perelman School of Medicine, Children's Hospital of Philadelphia/University of Pennsylvania, Philadelphia, PA USA.
Brigitte C WidemannPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Amanda E JanitzDepartment of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Jean Paul TannerChiles Center, College of Public Health, University of South Florida, Tampa, FL, USA.
Russell S KirbyChiles Center, College of Public Health, University of South Florida, Tampa, FL, USA.
Jason L SalemiChiles Center, College of Public Health, University of South Florida, Tampa, FL, USA.
Logan G SpectorDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Chad D HuffDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston TX USA.
Sharon E PlonDivision of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Philip J LupoDivision of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX USA.

Funding

Integrating Epidemiologic and Genomic Data to Elucidate the Genetic Overlap Between Congenital Anomalies and Pediatric CancerR01CA284531 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Chad Daniel Huff, Philip Lupo · 2023 to 2026
$1.9M
NCI NIH HHS R01 CA284531
6 · The paper itself

Abstract

backgroundBirth defects are associated with childhood cancer, but little is known regarding pediatric carcinomas, a group of especially rare tumors.

methodsWe used Cox proportional hazards regression to estimate the hazard ratio (HR) and 95 % confidence interval (CI) for any carcinoma, as well as thyroid, hepatocellular, and renal carcinoma specifically, up to 18 years of age among children with major, non-syndromic anomalies or chromosomal/genetic syndromes, relative to unaffected children.

resultsOur registry-linkage study included nine states and 21,933,476 children between 1990 and 2018: 641,827 with non-syndromic anomalies, and 49,619 with syndromes. Carcinomas were diagnosed in 833 children, including 35 with non-syndromic anomalies and eight with syndromes. The hazard of carcinoma was increased both among children with non-syndromic anomalies (HR: 1.7, CI: 1.2-2.4; N = 35) and syndromes (HR: 4.7, CI: 2.3-9.5; N = 7). Hepatocellular carcinoma was associated with non-syndromic anomalies (HR: 4.6, CI: 2.2-9.7; N = 8) and syndromes (HR: 8.0, CI: 1.1-58.1; N < 5). The hazard of renal carcinoma was markedly increased in children with tuberous sclerosis (HR 59.6, CI: 23.7-149.5; N = 5), a known cause of renal cancer. Thyroid carcinoma was not associated with non-syndromic anomalies or syndromes.

conclusionBirth defects are associated with hepatocellular and renal carcinoma in children.

Indexed as

Carcinoma, HepatocellularCongenital AbnormalitiesKidney NeoplasmsLiver NeoplasmsThyroid NeoplasmsAdolescentChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleProportional Hazards ModelsRegistriesRisk FactorsBirth defectsCarcinomaChildhood cancerCongenital anomaliesEpidemiology

Identifiers

PMID39848200
PMCPMC12977284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.