Evidence map›Paper›PMID 39847625›Full record

ArticleScience (New York, N.Y.)2025

Systematic identification of Y-chromosome gene functions in mouse spermatogenesis.

Jeremie Subrini, Wazeer Varsally, Irina Balaguer Balsells, Maike Bensberg, Georgios Sioutas, Obah Ojarikre, Valdone Maciulyte, Björn Gylemo, Katharine Crawley, Katherine Courtis and 2 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jeremie SubriniSex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK.ORCID 0000-0001-5633-0509
Wazeer VarsallySex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK.ORCID 0000-0002-4988-4551
Irina Balaguer BalsellsSex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK.ORCID 0009-0004-6636-7144
Maike BensbergSex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK.ORCID 0000-0003-2395-6083
Georgios SioutasSex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK.ORCID 0000-0002-4804-2109
Obah OjarikreSex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK.
Valdone MaciulyteSex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK.ORCID 0009-0005-9627-7163
Björn GylemoSex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK.ORCID 0000-0001-5253-6737
Katharine CrawleyGenetic Modification Service (GeMS), The Francis Crick Institute, London, UK.ORCID 0000-0003-3731-4786
Katherine CourtisGenetic Modification Service (GeMS), The Francis Crick Institute, London, UK.ORCID 0009-0001-2730-3349
Dirk G de RooijReproductive Biology Group, Division of Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands.ORCID 0000-0003-3932-4419
James M A TurnerSex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK.ORCID 0000-0003-1722-7677

Funding

Wellcome Trust CC2052
6 · The paper itself

Abstract

The mammalian Y chromosome is essential for male fertility, but which Y genes regulate spermatogenesis is unresolved. We addressed this by generating 13 Y-deletant mouse models. In

Indexed as

DNA-Binding ProteinsGenes, Y-LinkedMinor Histocompatibility AntigensProteinsSpermatogenesisTranscription FactorsY ChromosomeAnimalsCell ProliferationChromosome DeletionChromosome PairingGene DeletionInfertility, MaleMaleMeiosisMiceDNA-Binding ProteinsEif2s3y protein, mouseMinor Histocompatibility AntigensNuclear ProteinsProteinsTranscription FactorsUty protein, mouseZfy2 protein, mouse

Identifiers

PMID39847625
PMCPMC7617377

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.