ArticleCell reports2025
A cortico-subcortical loop for motor control via the pontine reticular formation.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Slc6a9 is distributed in glial cells and neurons across several nervous system regions, whereas Slc6a5 is more restricted to neurons in the caudal brain.BMC neuroscience · 2026Article
- Corticomuscular coupling study for post-stroke rehabilitation: a scoping review.Journal of neuroengineering and rehabilitation · 2025Article
- Convergence and Segregation of Excitatory and Inhibitory Afferents in the Paraventricular Thalamic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dynamic changes of serotonin transporter expression in the prefrontal cortex evoked by aggressive social interactions.Neurobiology of stress · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Movement and locomotion are controlled by large neuronal circuits like the cortex-basal ganglia (BG)-thalamus loop. Besides the inhibitory thalamic output, the BG directly control movement via specialized connections with the brainstem. Whether other parallel loops with similar logic exist is presently unclear. Here, we demonstrate that the secondary motor and cingulate cortices (M2/Cg) target and strongly control the activity of glycine transporter 2-positive (GlyT2+) cells in the pontine reticular formation (PRF). In turn, PRF/GlyT2+ cells project to and powerfully inhibit the intralaminar/parafascicular nuclei of the thalamus (IL/Pf). M2/Cg cells co-innervate PRF/GlyT2+ cells and the IL/Pf. Thalamus-projecting PRF/GlyT2+ cells target ipsilateral subcortical regions distinct from BG targets. Activation of the thalamus-projecting PRF/GlyT2+ cells leads to contralateral turning. These results demonstrate that the PRF is part of a cortico-subcortical loop that regulates motor activity parallel to BG circuits. The cortico-PRF-thalamus loop can control turning synergistically with the BG loops via distinct descending pathways.
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