Evidence map›Paper›PMID 39847463›Full record

ReviewAnnual review of pharmacology and toxicology2025

Toluene Toxicity in the Brain: From Cellular Targets to Molecular Mechanisms.

Andrew A Shaw, Jeffery D Steketee, Anna N Bukiya, Alex M Dopico

Abstract readReview
In one paragraph

Review in Annual review of pharmacology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Occupational hazard exposures among archivists.Frontiers in public health · 2025
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew A ShawDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA; email: adopico@uthsc.edu.
Jeffery D SteketeeDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA; email: adopico@uthsc.edu.
Anna N BukiyaDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA; email: adopico@uthsc.edu.
Alex M DopicoDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA; email: adopico@uthsc.edu.

Funding

Ionic mechanisms of toluene cerebrovascular actionsR01ES033158 · NIEHS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Anna Bukiya, Alex Dopico · 2022 to 2026
$2.2M
NIEHS NIH HHS R01 ES033158
6 · The paper itself

Abstract

Toluene intoxication constitutes a persistent public health problem worldwide. While most organs can be damaged, the brain is a primary target whether exposure is accidental, occupational, or recreational. Interventions to prevent/revert brain damage by toluene are curtailed by the scarce information on the molecular targets and mechanisms mediating toluene's brain toxicity and the common exposure to other neurotoxins and/or coexistence of neurological/psychiatric disorders. We examine (

Indexed as

BrainTolueneAnimalsHumansNeurogliaNeuronsNeurotoxicity SyndromesToluenebrain vesselsgliamembrane lipidsneuronsprotein receptorstoluene brain intoxication

Identifiers

PMID39847463
PMCPMC12928535

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.