Evidence map›Paper›PMID 39847366›Full record

ArticleInvestigative ophthalmology & visual science2025

Eye Movements and the Intraorbital Subarachnoid Space: Potential Contribution of Altered Cerebrospinal Fluid Pumping in Optic Neuropathies.

Joseph L Demer, Robert A Clark, Soh Youn Suh, JoAnn A Giaconi, Kouros Nouri-Mahdavi, Simon K Law, Laura Bonelli, Anthony C Arnold, Peter Quiros, Anne L Coleman and 1 more

Abstract read
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In one paragraph

Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Optic Disc and Retinal Strain Due to Vertical Duction.Investigative ophthalmology & visual science · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joseph L DemerDepartment of Ophthalmology, University of California, Los Angeles, California, United States.
Robert A ClarkDepartment of Ophthalmology, University of California, Los Angeles, California, United States.
Soh Youn SuhDepartment of Ophthalmology, University of California, Los Angeles, California, United States.
JoAnn A GiaconiDepartment of Ophthalmology, University of California, Los Angeles, California, United States.
Kouros Nouri-MahdaviDepartment of Ophthalmology, University of California, Los Angeles, California, United States.
Simon K LawDepartment of Ophthalmology, University of California, Los Angeles, California, United States.
Laura BonelliDepartment of Ophthalmology, University of California, Los Angeles, California, United States.
Anthony C ArnoldDepartment of Ophthalmology, University of California, Los Angeles, California, United States.
Peter QuirosDepartment of Ophthalmology, University of California, Los Angeles, California, United States.
Anne L ColemanDepartment of Ophthalmology, University of California, Los Angeles, California, United States.
Joseph CaprioliDepartment of Ophthalmology, University of California, Los Angeles, California, United States.

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERYR01EY008313 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOSEPH Louis DEMER · 1991 to 2026
$15.0M
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY008313
6 · The paper itself

Abstract

Purpose: The optic nerve (ON) is mechanically perturbed by eye movements that shift cerebrospinal fluid (CSF) within its surrounding dural sheath. This study compared changes in ON length and CSF volume within the intraorbital ON sheath caused by eye movements in healthy subjects and patients with optic neuropathies. Methods: Twenty-one healthy controls were compared with 11 patients having primary open angle glaucoma (POAG) at normal intraocular pressure (IOP), and 11 with chronic non-arteritic anterior ischemic optic neuropathy (NA-AION). High resolution magnetic resonance imaging (MRI) was performed in central and eccentric gazes, and analyzed to determine ON partial volume and gaze-related changes in ON path redundancy, ON elongation, and intrasheath CSF volume. Results: ON volume was subnormal in both POAG and NA-AION. In all subjects, ON path redundancy decreased similarly from abduction to central gaze to adduction; in healthy subjects, the ON path was also significantly less redundant in infraduction and supraduction. The ON elongated significantly in adduction in controls and NA-AION but not in POAG. In all groups, CSF volume was 40 to 50 mm3 in central gaze, and significantly decreased in adduction, abduction, and supraduction in controls but subnormally in adduction only in POAG and NA-AION. The globe translated laterally more than normal in NA-AION but did not retract. Conclusions: Horizontal gaze and supraduction change subarachnoid CSF volume around the retrobulbar ON. Eye movements might thus pump CSF to promote ON health, but this effect is subnormal in adduction in POAG and NA-AION, suggesting that retrobulbar CSF pumping is associated with chronic forms of these optic neuropathies.

Indexed as

Cerebrospinal FluidEye MovementsGlaucoma, Open-AngleOptic Nerve DiseasesOptic Neuropathy, IschemicOrbitSubarachnoid SpaceAdultAgedCerebrospinal Fluid PressureFemaleHumansIntraocular PressureMagnetic Resonance ImagingMaleMiddle Aged

Identifiers

PMID39847366
PMCPMC11758931

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.