Evidence map›Paper›PMID 39847335›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A carnitine transporter at the blood-brain barrier modulates sleep via glial lipid metabolism in

Ashley Avila, Ava S Lewandowski, Yongjun Li, Jesse Gui, Kaeun A Lee, Zhenglang Yang, Mari Kim, James T Lyles, Kai Man, Amita Sehgal and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ashley Avila *Department of Cell Biology, Emory University, Atlanta, GA 30322.
Ava S Lewandowski *Department of Cell Biology, Emory University, Atlanta, GA 30322.
Yongjun LiHHMI, University of Pennsylvania, Philadelphia, PA 19104.
Jesse GuiDepartment of Cell Biology, Emory University, Atlanta, GA 30322.
Kaeun A LeeDepartment of Cell Biology, Emory University, Atlanta, GA 30322.
Zhenglang YangDepartment of Cell Biology, Emory University, Atlanta, GA 30322.
Mari KimDepartment of Cell Biology, Emory University, Atlanta, GA 30322.
James T LylesDepartment of Pediatrics, Emory University, Atlanta, GA 30322.
Kai ManDepartment of Cell Biology, Emory University, Atlanta, GA 30322.
Amita SehgalHHMI, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0001-7354-9641
Joshua D ChandlerDepartment of Pediatrics, Emory University, Atlanta, GA 30322.ORCID 0000-0003-3211-7935
Shirley L ZhangDepartment of Cell Biology, Emory University, Atlanta, GA 30322.ORCID 0000-0002-6672-2044

Funding

Neutrophil hyperexocytosis and hypochlorous acid exposure in early cystic fibrosis lung diseaseR01HL150658 · NHLBI · EMORY UNIVERSITY · PI Joshua D Chandler · 2023 to 2026
$1.5M
Determining the importance of temporal regulation of the blood-brain barrierR00HL147212 · NHLBI · EMORY UNIVERSITY · PI ZHANG, SHIRLEY · 2021 to 2023
$857k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R00HL147212HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL150658Howard Hughes Medical Institute (HHMI) N/ANHLBI NIH HHS R00 HL147212NHLBI NIH HHS R01 HL150658
6 · The paper itself

Abstract

To regulate brain function, peripheral compounds must traverse the blood-brain barrier (BBB), an interface between the brain and the circulatory system. To determine whether specific transport mechanisms are relevant for sleep, we conducted a BBB-specific inducible RNAi knockdown (iKD) screen for genes affecting sleep in

Indexed as

Blood-Brain BarrierCarnitineDrosophila melanogasterDrosophila ProteinsLipid MetabolismNeurogliaSleepAnimalsBiological TransportBrainFatty AcidsCarnitineDrosophila ProteinsFatty Acidsblood-brain barriercarnitine transportfatty acidslipid metabolismsleep regulation

Identifiers

PMID39847335
PMCPMC11789159

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.