ArticleProceedings of the National Academy of Sciences of the United States of America2025
Calcineurin governs baseline and homeostatic regulations of non-rapid eye movement sleep in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A molecular integrator of sleep duration and interruption.bioRxiv : the preprint server for biology · 2026Article
- Active zone plasticity couples sleep need to presynaptic hypophosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Zebrafish neurofibromatosis type 1 mutants show disruption of sleep but not of circadian rhythms.Sleep · 2026Article
- Tuina ameliorates sleep disturbances in PCPA-treated rats through Piezo1-mediated calcium signaling.Frontiers in pharmacology · 2026Article
- Biological Mechanisms of Sleep/Wake-Related Function.Biological psychiatry · 2025Review
- PP2Acα regulates sleep amount and sleep homeostasis in mice.Communications biology · 2025Article
- Calcineurin goes to sleep.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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15 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Sleep need accumulates during waking and dissipates during sleep to maintain sleep homeostasis (process S). Besides the regulation of daily (baseline) sleep amount, homeostatic sleep regulation commonly refers to the universal phenomenon that sleep deprivation (SD) causes an increase of sleep need, hence, the amount and intensity of subsequent recovery sleep. The central regulators and signaling pathways that govern the baseline and homeostatic sleep regulations in mammals remain unclear. Here, we report that enhanced activity of calcineurin Aα (CNAα)-a catalytic subunit of calcineurin-in the mouse brain neurons sharply increases the amount (to ~17-h/d) and delta power-a measure of intensity-of non-rapid eye movement sleep (NREMS). Knockout of the regulatory (
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