Evidence map›Paper›PMID 39847324›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Light signal regulates endoreduplication and tomato fruit expansion through the SlPIF1a-SlTLFP8-SlCDKB2 module.

Jiaojiao Zhang, Jiayi Xu, Xinman Wang, Ying Liu, Shuangtao Li, Jialong Zhang, Lingfeng He, Luqin Guo, Chonghua Li, Xin-Xu Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiaojiao Zhang *Beijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, College of Horticulture, China Agricultural University, Beijing 100193, China.
Jiayi Xu *Beijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, College of Horticulture, China Agricultural University, Beijing 100193, China.
Xinman WangBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, College of Horticulture, China Agricultural University, Beijing 100193, China.
Ying LiuBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, College of Horticulture, China Agricultural University, Beijing 100193, China.ORCID 0009-0007-9230-1888
Shuangtao LiBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, College of Horticulture, China Agricultural University, Beijing 100193, China.
Jialong ZhangBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, College of Horticulture, China Agricultural University, Beijing 100193, China.
Lingfeng HeBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, College of Horticulture, China Agricultural University, Beijing 100193, China.
Luqin GuoBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, College of Horticulture, China Agricultural University, Beijing 100193, China.
Chonghua LiBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, College of Horticulture, China Agricultural University, Beijing 100193, China.
Xin-Xu LiBeijing Cuihu Agritech Co. Ltd., Beijing 100095, China.
Yang-Dong GuoBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, College of Horticulture, China Agricultural University, Beijing 100193, China.
Na ZhangBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, College of Horticulture, China Agricultural University, Beijing 100193, China.ORCID 0009-0005-2591-599X

Funding

MOST | National Natural Science Foundation of China (NSFC) 32172598MOST | National Natural Science Foundation of China (NSFC) 32172599
6 · The paper itself

Abstract

Light serves as an energy source for cell division and expansion during fruit development. Cell expansion significantly influences fruit size and is closely linked to endoreduplication, a unique cell cycle variation characterized by DNA replication without cytokinesis. Paradoxically, under conditions of ample photosynthates, light signaling suppresses cell expansion. The intricate regulation of endoreduplication in response to light signaling during fruit development has remained an intriguing question. Here, our study revealed that Tubby-like F-box protein 8 (SlTLFP8) orchestrated endoreduplication to facilitate fruit cell expansion. As an Skp1-Cullin-F-box (SCF)-type E3 ligase, SlTLFP8 promoted the ubiquitination and subsequent degradation of CYCLIN-DEPENDENT KINASE B2 (SlCDKB2), thereby elevating DNA ploidy. The light signaling component PHYTOCHROME-INTERACTING FACTOR 1a (SlPIF1a), identified as a pivotal negative regulator in the plant's light response, was found to directly interact with the promoter of the

Indexed as

Cyclin-Dependent KinasesEndoreduplicationF-Box ProteinsFruitLight Signal TransductionPlant ProteinsSolanum lycopersicumGene Expression Regulation, PlantLightSignal TransductionUbiquitinationCyclin-Dependent KinasesF-Box ProteinsPlant Proteinscyclin-dependent kinaseF-box tubby-like proteinfruit sizephytochrome-interacting factorubiquitination

Identifiers

PMID39847324
PMCPMC11789079

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.