Evidence map›Paper›PMID 39847187›Full record

ArticleMolecular diversity2025

Discovery of selective ROCK2 inhibitors with free radical scavenging ability for the treatment of gouty arthritis.

Ruolin Cao, Chuqiao Song, Zhe Wang, Bingqing Lv, Wei Xiao, Guoliang Chen, Xuefei Bao

Abstract read
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In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruolin CaoKey Laboratory of Structure-Based Drugs Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, PR China.
Chuqiao SongKey Laboratory of Structure-Based Drugs Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, PR China.
Zhe WangKey Laboratory of Structure-Based Drugs Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, PR China.
Bingqing LvKey Laboratory of Structure-Based Drugs Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, PR China.
Wei XiaoJiangsu Kanion Pharmaceutical Co., Ltd, Lianyungang, 222001, P. R. China. xw_kanion@163.com.
Guoliang ChenKey Laboratory of Structure-Based Drugs Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, PR China. spucgl@163.com.
Xuefei BaoKey Laboratory of Structure-Based Drugs Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, PR China. bxf551@163.com.

Funding

the China Postdoctoral Science Foundation No. 2019M661132the foundation of Liaoning Provincial Department of Education No. LJKQZ20222351the National Natural Science Foundation of China No. 82273793
6 · The paper itself

Abstract

ROCK inhibitors can inhibit IL-1β and NLRP3, and their therapeutic potential for osteoarthritis and rheumatoid arthritis has been confirmed, but their impact on gouty arthritis has not been reported yet. By hybridization the structure of Edaravone, a series of ROCK inhibitors with pyrazolone scaffold were designed and synthesized. RM-04 has acceptable selective ROCK2 inhibitory activity with an IC

Indexed as

Arthritis, GoutyDrug DiscoveryFree Radical ScavengersProtein Kinase Inhibitorsrho-Associated KinasesAnimalsHumansMaleMiceUric AcidFree Radical ScavengersProtein Kinase Inhibitorsrho-Associated KinasesUric AcidAnti-inflammatoryFree radical scavengerGouty arthritisROCK2 inhibitor

Identifiers

PMID39847187

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.