Evidence map›Paper›PMID 39847128›Full record

ArticleSleep & breathing = Schlaf & Atmung2025

Evolution of sleep disordered breathing in infants with achondroplasia.

Janet M Legare, David G Ingram, Richard M Pauli, Jacqueline T Hecht, Lorena Dujmusic, David F Rodriguez-Buritica, Jeffrey W Campbell, Peggy Modaff, Mary E Little, Cory J Smid and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Foramen magnum decompression in infants and children with achondroplasia: clinical outcomes from a 15-patient surgical series.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Janet M Legare *University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. jmlegare@pediatrics.wisc.edu.
David G Ingram *University of Missouri Kansas City School of Medicine, Kansas City, MO, USA.ORCID 0000-0002-7285-2857
Richard M PauliUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Jacqueline T HechtMcGovern Medical School University of Texas Health, Houston, TX, USA.
Lorena DujmusicUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
David F Rodriguez-BuriticaMcGovern Medical School University of Texas Health, Houston, TX, USA.
Jeffrey W CampbellNemours Children's Hospital, Thomas Jefferson University, Wilmington, DE, USA.
Peggy ModaffUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Mary E LittleNemours Children's Hospital, Thomas Jefferson University, Wilmington, DE, USA.
Cory J SmidUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Maria E SernaMcGovern Medical School University of Texas Health, Houston, TX, USA.
Michael B BoberNemours Children's Hospital, Thomas Jefferson University, Wilmington, DE, USA.
Julie E Hoover-FongGreenberg Center for Skeletal Dysplasias, John Hopkins University, Baltimore, MD, USA.
S Shahrukh HashmiMcGovern Medical School University of Texas Health, Houston, TX, USA.

Funding

BioMarin Pharmaceutical 188299
6 · The paper itself

Abstract

purposeChildren with achondroplasia (ACH) are at risk for sudden death in infancy due to sleep disordered breathing (SDB) and foramen magnum stenosis (FMS). Sleep studies and neuroimaging are performed in infants with ACH, but interpretation of infant studies is challenging. We sought to describe baseline data on polysomnography (PSG) indices in infants with achondroplasia as well as effects of age and surgery on these parameters.

methodsRetrospective data were abstracted from the multisite CLARITY ACH database from years 2008-2017. Both obstructive apnea hypopnea index (OAHI) and central apnea index (CAI) were extracted, and effects of age and surgical intervention (adenoidectomy [AD] or cervicomedullary decompression [CMD]) were analyzed.

results172 PSGs from 86 infants were analyzed. In surgically naive children, OAHI decreased over the first year but then increased in the second year, while CAI was mostly stagnant over the first two years. There were no significant differences between age at first PSG or PSG indices for surgically naive infants versus those who underwent AD or CMD. OAHI decreased after AD and CAI decreased after CMD.

conclusionSimilar to average stature infants, our results demonstrate the need to interpret sleep study findings of children with ACH in the context of age, particularly for obstructive indices. Neither OAHI nor CAI differentiated those infants who subsequently underwent surgery, suggesting that there were other important clinical factors in the surgical decision-making process. Independent of age, AD resulted in improvement in OSA and CMD with improvement in central sleep apnea.

Indexed as

AchondroplasiaSleep Apnea SyndromesAdenoidectomyChild, PreschoolDecompression, SurgicalFemaleHumansInfantMalePolysomnographyRetrospective StudiesSleep Apnea, CentralSleep Apnea, ObstructiveAchondroplasiaAdenoidectomyCervicomedullary decompressionInfant polysomnogram

Identifiers

PMID39847128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.