Evidence map›Paper›PMID 39847077›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Prognostic

Amir Karimzadeh, Kimberley Hansen, Ergela Hasa, Bernhard Haller, Matthias M Heck, Robert Tauber, Calogero D Alessandria, Wolfgang A Weber, Matthias Eiber, Isabel Rauscher

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Baseline PSMA PET/CT Biomarkers for Patient Selection in [Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amir Karimzadeh *Department of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany. amir.karimzadeh@uke.de.
Kimberley Hansen *Department of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Ergela HasaDepartment of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Bernhard HallerInstitute of AI and Informatics in Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Matthias M HeckDepartment of Urology, School of Medicine, Technical University of Munich, Munich, Germany.
Robert TauberDepartment of Urology, School of Medicine, Technical University of Munich, Munich, Germany.
Calogero D AlessandriaDepartment of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Wolfgang A WeberDepartment of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Matthias EiberDepartment of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Isabel RauscherDepartment of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis retrospective analysis evaluates baseline

methodsA total of 188 mCRPC patients with baseline

resultsSignificant prognostic parameters for PSA response and PSA-PFS included log-transformed whole-body SUVmax (odds ratio (OR), 3.26, 95% confidence interval (CI), 2.01-5.55 and hazard ratio (HR), 0.51, 95% CI, 0.4-0.66; both p < 0.001) and prior chemotherapy (OR 0.3, 95% CI, 0.12-0.72 and HR 1.64, 95% CI, 1.07-2.58; p = 0.008 and p = 0.028, respectively). For OS, significant prognosticators were the following log-transformed parameters: number of lesions (HR 1.38, 95% CI, 1.24-1.53; p < 0.001), TTV (HR 1.27, 95% CI, 1.18-1.37; p < 0.001), and ITLV (HR 1.24, 95% CI, 1.16-1.33; p < 0.001), with log-transformed TTV (HR 1.15, 95% CI, 1.04-1.27; p = 0.008) remaining significant in multivariate analysis.

conclusionAt baseline, SUV-based

Indexed as

Antigens, SurfaceGlutamate Carboxypeptidase IILutetiumPositron-Emission TomographyProstatic Neoplasms, Castration-ResistantAgedAged, 80 and overHumansMaleMiddle AgedNeoplasm MetastasisPrognosisRadioisotopesRadiopharmaceuticalsRetrospective StudiesTreatment OutcomeAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IILutetiumLutetium-177RadioisotopesRadiopharmaceuticals[177Lu]Lu-PSMA-I&T18F-flotufolastatmCRPCPSMARadioligand therapy

Identifiers

PMID39847077
PMCPMC12014739

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.