Evidence map›Paper›PMID 39847051›Full record

ArticleVirchows Archiv : an international journal of pathology2025

ACTB::ZMIZ2-rearranged adnexal carcinoma: a second case.

Carina Dehner, Daniel Pissaloux, Brice Thamphya, Franck Tirode, Andreas Von Deimling, Ruifeng R Guo, Carilyn Wieland, Arnaud de la Fouchardière, Thibault Kervarrec

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Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Carina DehnerDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Daniel PissalouxDepartment of Biopathology, Center Léon Bérard, Lyon, France.
Brice ThamphyaDepartment of Biopathology, Center Léon Bérard, Lyon, France.
Franck TirodeDepartment of Biopathology, Center Léon Bérard, Lyon, France.
Andreas Von DeimlingDepartment of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany.
Ruifeng R GuoDepartment of Laboratory Medicine and Pathology, Mayo Clinic Florida, Jacksonville, FL, USA.
Carilyn WielandDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Arnaud de la FouchardièreDepartment of Biopathology, Center Léon Bérard, Lyon, France.
Thibault KervarrecDepartment of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, 37044, Tours, France. thibaultkervarrec@yahoo.fr.ORCID http://orcid.org/0000-0002-2201-6914

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A case of cutaneous adnexal neoplasm with unusual squamoid morphology and harboring an in frame ACTB::ZMIZ2 fusion transcript was recently described. Herein, we report a second case of adnexal carcinoma harboring similar morphology and an identical in frame ACTB::ZMIZ2 fusion transcript. This 2.2-cm mass was removed from the axilla of a 17-year-old woman. Microscopic examination revealed a large nodular and infiltrative tumor invading the dermis composed of sheets and nests frequently centered by large areas of keratinization. Molecular investigation revealed an in frame ACTB::ZMIZ2 fusion transcript. Clustering analysis revealed close proximity of this case with the ACTB::ZMIZ2-fused adnexal tumor previously reported. Herein, we report a second case of adnexal tumor with ACTB::ZMIZ2 fusion arising in a young adult suggesting that ACTB::ZMIZ2 fusion might be a defining genetic event, specific of a rare and previously undescribed adnexal tumor entity.

Indexed as

CarcinomaNeoplasms, Adnexal and Skin AppendageOncogene Proteins, FusionAdolescentAxillaDermisExome SequencingFemaleHumansOncogene Proteins, FusionACTB::ZMIZ2AdnexalPorocarcinomaTrichilemmal

Identifiers

PMID39847051

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.