Evidence map›Paper›PMID 39846740›Full record

ArticleJournal of virology2025

Immunological findings of West Caucasian bat virus in an accidental host.

Martina Castellan, Gianpiero Zamperin, Greta Foiani, Maira Zorzan, Maria Francesca Priore, Petra Drzewnioková, Erica Melchiotti, Marta Vascellari, Isabella Monne, Sergio Crovella and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Martina CastellanLaboratory for Emerging Viral Zoonoses, WOAH Reference Laboratory for Rabies, FAO and National Reference Centre for Rabies, Department for Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.ORCID 0000-0003-0672-0706
Gianpiero ZamperinViral Genomics and Transcriptomics Laboratory, Department for Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.ORCID 0000-0003-0600-5163
Greta FoianiLaboratory of Histopathology, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Maira ZorzanLaboratory for Emerging Viral Zoonoses, WOAH Reference Laboratory for Rabies, FAO and National Reference Centre for Rabies, Department for Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Maria Francesca PrioreLaboratory for Emerging Viral Zoonoses, WOAH Reference Laboratory for Rabies, FAO and National Reference Centre for Rabies, Department for Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Petra DrzewniokováLaboratory for Emerging Viral Zoonoses, WOAH Reference Laboratory for Rabies, FAO and National Reference Centre for Rabies, Department for Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Erica MelchiottiLaboratory of Histopathology, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Marta VascellariLaboratory of Histopathology, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Isabella MonneViral Genomics and Transcriptomics Laboratory, Department for Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Sergio CrovellaLaboratory of Animal Research Center (LARC), Qatar University, Doha, Qatar.
Stefania LeopardiLaboratory for Emerging Viral Zoonoses, WOAH Reference Laboratory for Rabies, FAO and National Reference Centre for Rabies, Department for Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Paola De BenedictisLaboratory for Emerging Viral Zoonoses, WOAH Reference Laboratory for Rabies, FAO and National Reference Centre for Rabies, Department for Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.ORCID 0000-0001-6760-1933

Funding

Ministero della Salute (Italy Ministry of Health) RC IZSVe 07/2022
6 · The paper itself

Abstract

The IMPORTANCE: Although all lyssaviruses cause fatal encephalomyelitis in mammals, they display a different host tropism and pathogenicity, with the ecology of Rabies virus (RABV) continually evolving and adapting to new host species. In 2020, West Caucasian bat virus (WCBV) was identified as the causative agent of rabies in a domestic cat in Italy. This event raised concerns about its public health consequences, due to the absence of biologicals against the infection. Our study investigates the host immune response triggered by WCBV in comparison with a pathogenic strain of RABV and the low pathogenic Duvenhage lyssavirus (DUVV), as a proxy to understand the mechanisms leading to lyssavirus spillover and pathogenicity. We overall confirm that previous evidence indicating an inverse relationship between lyssavirus pathogenicity and immune response is applicable for WCBV as well. Importantly, this work represents the first transcriptomic analysis of the WCBV interaction in the central nervous system with an accidental host.

Indexed as

LyssavirusRhabdoviridae InfectionsAnimalsCatsCricetinaeMesocricetusRabiesRabies virusDuvenhage virus (DUVV)host responserabies virus (RABV)Syrian hamstertranscriptomic analysisWest Caucasian bat virus (WCBV)

Identifiers

PMID39846740
PMCPMC11853057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.