Evidence map›Paper›PMID 39846701›Full record

ArticleMedical sciences (Basel, Switzerland)2025

Whole-Genome Sequencing of Resistance, Virulence and Regulation Genes in Extremely Resistant Strains of

Nerlis Pajaro-Castro, Erick Diaz-Morales, Kenia Hoyos, Cristhian Ibañez-Bersinger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical sciences (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Metallo-β-lactamase-producingFrontiers in microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nerlis Pajaro-CastroMedical and Pharmaceutical Sciences Group, Faculty of Health Sciences, University of Sucre, Sincelejo 700001, Sucre, Colombia.ORCID 0000-0002-9831-9663
Erick Diaz-MoralesSalud Social Clinic, Sincelejo 700001, Sucre, Colombia.ORCID 0000-0002-8451-6930
Kenia HoyosSalud Social Clinic, Sincelejo 700001, Sucre, Colombia.ORCID 0000-0003-0203-2367
Cristhian Ibañez-BersingerMedical and Pharmaceutical Sciences Group, Faculty of Health Sciences, University of Sucre, Sincelejo 700001, Sucre, Colombia.

Funding

Ministerio de Ciencia, Tecnología e Innovación 320-2023
6 · The paper itself

Abstract

BACKGROUND/

objectives

methodsAntibiotic susceptibility was assessed using the Minimum Inhibitory Concentration (MIC) method, and whole-genome sequencing (WGS) was performed on the Illumina NovaSeq platform.

resultsThe analysis demonstrated a higher prevalence of virulence genes compared to resistance and regulatory genes. Key virulence factors identified included secretion systems, motility, adhesion, and biofilm formation. Resistance mechanisms observed comprised efflux pumps and beta-lactamases, while regulatory systems involved two-component systems, transcriptional regulators, and sigma factors. Additionally, phenotypic profiles were found to correlate with resistance genes identified through genotypic analysis.

conclusionsThis study underscores the significant resistance and virulence of the clinical

Indexed as

Drug Resistance, BacterialPseudomonas aeruginosabeta-LactamasesFemaleGenes, BacterialGenotypeHumansMaleMicrobial Sensitivity TestsMiddle AgedPseudomonas InfectionsVirulenceWhole Genome Sequencingbeta-Lactamasesbeta-lactamasesbiofilmsefflux pumpsregulatory genesresistance genessecretion systemsvirulence genes

Identifiers

PMID39846701
PMCPMC11755660

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.