Evidence map›Paper›PMID 39846540›Full record

ArticleJournal of xenobiotics2025

Reducing the Formation of Toxic Byproducts During the Photochemical Release of Epinephrine.

Mikhail A Panfilov, Ezhena S Starodubtseva, Tatyana Yu Karogodina, Alexey Yu Vorob'ev, Alexander E Moskalensky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of xenobiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mikhail A PanfilovN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia.ORCID 0000-0001-6865-2687
Ezhena S StarodubtsevaDepartment of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia.
Tatyana Yu KarogodinaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia.
Alexey Yu Vorob'evN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia.
Alexander E MoskalenskyDepartment of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia.ORCID 0000-0002-9710-7757

Funding

Russian Science Foundation 23-75-10049
6 · The paper itself

Abstract

Engineered light-sensitive molecules offer a sophisticated toolkit for the manipulation of biological systems with both spatial and temporal precision. Notably, artificial "caged" compounds can activate specific receptors solely in response to light exposure. However, the uncaging process can lead to the formation of potentially harmful byproducts. For example, the photochemical release of adrenaline (epinephrine) is accompanied by the formation of adrenochrome, which has neuro- and cardiotoxic effects. To investigate this effect in detail, we synthesized and compared two "caged" epinephrine analogs. The first was a classical compound featuring an

Indexed as

adrenochromecaged compoundsepinephrinephotopharmacologyplatelet activation

Identifiers

PMID39846540
PMCPMC11755455

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.