Evidence map›Paper›PMID 39846509›Full record

ArticleBiotechnology progress

Process intensification of the baculovirus expression vector system using a perfusion process with a low multiplicity of infection at high cell concentrations.

Jort J Altenburg, Brenda E Juarez-Garza, Jelle van Keimpema, Linda van Oosten, Gorben P Pijlman, Monique M van Oers, René H Wijffels, Dirk E Martens

Abstract read
In one paragraph

Article in Biotechnology progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jort J AltenburgBioprocess Engineering, Wageningen University & Research, Wageningen, The Netherlands.
Brenda E Juarez-GarzaBioprocess Engineering, Wageningen University & Research, Wageningen, The Netherlands.
Jelle van KeimpemaBioprocess Engineering, Wageningen University & Research, Wageningen, The Netherlands.
Linda van OostenLaboratory of Virology, Wageningen University & Research, Wageningen, The Netherlands.
Gorben P PijlmanLaboratory of Virology, Wageningen University & Research, Wageningen, The Netherlands.
Monique M van OersLaboratory of Virology, Wageningen University & Research, Wageningen, The Netherlands.
René H WijffelsBioprocess Engineering, Wageningen University & Research, Wageningen, The Netherlands.
Dirk E MartensBioprocess Engineering, Wageningen University & Research, Wageningen, The Netherlands.ORCID 0000-0002-5662-0466

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek 16762
6 · The paper itself

Abstract

The emergence of new viruses and the spread of existing pathogens necessitate efficient vaccine production methods. The baculovirus expression vector system (BEVS) is an efficient and scalable system for subunit and virus-like particle vaccine production and gene therapy vectors. However, current production processes are often limited to low cell concentrations (1-4 × 10

Indexed as

BaculoviridaeGenetic VectorsAnimalsBatch Cell Culture TechniquesGreen Fluorescent ProteinsSf9 CellsGreen Fluorescent Proteinsbaculovirus expression vector systeminsect cell cultureperfusionprocess intensification

Identifiers

PMID39846509
PMCPMC12171338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.