Evidence map›Paper›PMID 39846482›Full record

ArticleMovement disorders clinical practice2025

Early Motor Signs in Pathologically Verified Alzheimer's Disease and Lewy Body Disease.

Daniel M Oh, Jocelyn M Jiao, Xinhui Wang, Ashim Ahuja, Nenette A Caceres, Kristi A Clark, Helena Chui, John M Ringman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel M OhDepartment of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-8833-1001
Jocelyn M JiaoDepartment of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Xinhui WangDepartment of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Ashim AhujaDepartment of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Nenette A CaceresCancer Research Center for Health Equity, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Kristi A ClarkDepartment of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Helena ChuiDepartment of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
John M RingmanDepartment of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.

Funding

NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
UCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CUMMINGS, JEFFREY L. · 1999 to 2014
$25.9M
NIA NIH HHS P30 AG066530NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG016570NIA NIH HHS P50 AG16570NIA NIH HHS U01 AG016976NIA NIH HHS U24 AG072122
6 · The paper itself

Abstract

backgroundThe neuropathologies of Alzheimer's disease (AD) and Lewy body disease (LBD) commonly co-occur. Parkinsonism is the hallmark feature in LBD but it can be difficult to predict the presence of these co-pathologies early in the course of clinical disease. Timely diagnosis has crucial implications, especially with the advent of disease-modifying therapies.

objectivesWe sought to define early motor features that predict the ultimate neuropathological diagnoses of normal, AD, AD with concurrent LB pathology, and pure LB.

methodsWe examined the associations between individuals' early motor features from their initial visit using the Unified Parkinson's Disease Rating Scale (UPDRS) Part III and their neuropathological diagnoses using the U.S. National Alzheimer's Coordinating Center (NACC) Database.

resultsWe included data from participants with neuropathologically normal brains (n = 49), AD (n = 502), AD w/LB (n = 167), and pure LB (n = 51). Total UPDRS Part III scores were increasingly higher with purer LB pathology. Decreased facial expression at baseline differentiated those with AD w/LB pathology from those with AD. Participants having pure LB pathology more often had deficits in speech, facial expression, posture, gait, bradykinesia, and upper extremity rigidity relative to those with AD w/LB.

conclusionDiminished facial expression significantly predicted the presence of LBs among those with concurrent AD pathology. Worse early speech, facial expression, posture, gait, bradykinesia, and upper extremity rigidity were suggestive of more pure LB pathology. These findings emphasize the utility of the neurological exam in the clinical assessment of persons with cognitive complaints as it can guide management.

Indexed as

Alzheimer DiseaseLewy Body DiseaseAgedAged, 80 and overBrainFemaleHumansMaleAlzheimer's diseaseLewy body diseasemotor featuresParkinsonism

Identifiers

PMID39846482
PMCPMC12187982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.