Evidence map›Paper›PMID 39846368›Full record

ArticleClinical and experimental rheumatology2025

Stressful life events are associated with the diagnosis of systemic autoimmune rheumatic diseases among adults.

Iazsmin Bauer Ventura, Maya E Goldberg, Adam Schiffenbauer, Min Shi, Rita Volochayev, Sharon H Jackson, Anna Jansen, Nastaran Bayat, Payam Noroozi Farhadi, Christine G Parks and 4 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Iazsmin Bauer VenturaSection of Rheumatology, Department of Medicine, University of Chicago, IL, USA.
Maya E GoldbergEnvironmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA.
Adam SchiffenbauerEnvironmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA.
Min ShiBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Rita VolochayevEnvironmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA.
Sharon H JacksonNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Anna JansenEnvironmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA.
Nastaran BayatEnvironmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA, and Social Scientific System Inc, a DLH holding company.
Payam Noroozi FarhadiEnvironmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA.
Christine G ParksEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Clarice R WeinbergBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Angelo PicardiCentre for Behavioural Sciences and Mental Health, Italian National Institute of Health, Rome, Italy.
Frederick W MillerEnvironmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA.
Lisa G RiderEnvironmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, and Research Triangle Park, NC, USA. riderl@mail.nih.gov.

Funding

Environmental/genetic Risk Factors and Pathogenesis of Autoimmune DiseaseZIAES101074 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RIDER, LISA · 2009 to 2025
$34.6M
SCIENTIFIC, OPERATIONS, AND ADMINISTRATIVE RESOURCES (SOAR) TO NIH.75N95021D00012 · NIDA · KELLY SERVICES, INC. · PI SPROSE, SARA · 2021 to 2021
$57k
Intramural NIH HHS ZIA ES101074NIDA NIH HHS 75N95021D00012NIEHS NIH HHS HHSN273201600002CNIEHS NIH HHS HHSN273201600021C
6 · The paper itself

Abstract

objectivesTo assess the association between life events and subsequent diagnosis of systemic autoimmune rheumatic diseases (SARDs) by comparing siblings discordant for SARDs and unrelated controls.

methodsLife events 12 months prior to SARD diagnosis/reference date were queried using the Interview for Recent Life Events in 227 adults (96 probands with SARDs, 78 siblings, 53 controls). Probands were matched by age, sex, and race with their unaffected siblings or with unrelated controls. Logistic regression was used to calculate the relative odds of SARDs in relation to life events scores, adjusting for age, sex, race/ethnicity, education, and ever smoking.

resultsThe study identified consistent trends of probands reporting greater numbers of total and highly stressful events, and higher stress ratings than their unaffected siblings. Probands reported greater numbers and higher stress ratings of total, uncontrollable, and undesirable events compared to unrelated controls (p<0.001-0.024). The number of highly stressful events and the scores of weighted major events were also greater in probands and siblings compared to unrelated controls (p<0.001-0.046). The number of total, major, uncontrollable, undesirable, and highly stressful life events (OR range 1.31-1.64, p-value range 0.001-0.049), along with their corresponding stress ratings (OR range 1.22-1.51, p-value range <0.001-0.016), were associated with higher odds of SARD diagnosis, based on probands compared to controls.

conclusionsThis case-control study of life events preceding SARDs diagnosis using a validated life events questionnaire provides support for an aetiologic role of negative life events and psychological stress in SARDs among adults.

Indexed as

Autoimmune DiseasesLife Change EventsRheumatic DiseasesStress, PsychologicalAdultAgedCase-Control StudiesFemaleHumansLogistic ModelsMaleMiddle AgedOdds RatioRisk FactorsSiblingsSurveys and Questionnaires

Identifiers

PMID39846368
PMCPMC11890514

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.