ArticleJournal of the American Heart Association2025
Comprehensive Assessment of the Risk of Symptomatic Embolism in Patients With Infective Endocarditis.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Contemporary Clinical Spectrum and Factors Associated with Mortality in Infective Endocarditis: A Multicenter Cohort Study (COSMO-IE).Journal of clinical medicine · 2026Article
- Paradoxical sparing of cerebral circulation in massive TAVR-associated endocarditis.Journal of cardiothoracic surgery · 2026Article
- Embolic Burden and Echocardiographic Predictors in a Real-World Cohort of Infective Endocarditis: A 15-Year Single-Center Retrospective Study.Journal of clinical medicine · 2026Article
- Infective Endocarditis: A Contemporary Review of Epidemiology, Diagnosis, and Management.Antibiotics (Basel, Switzerland) · 2026Review
- Mind the Gap: Inadequate Performance of Embolic Risk Scores in Infective Endocarditis.Open forum infectious diseases · 2026Article
- Systemic Embolic Events in People Who Inject Drugs With Patent Foramen Ovale and Right-Sided Infective Endocarditis: A Systematic Review.Open forum infectious diseases · 2026Article
- Current Management of Infective Endocarditis: A Narrative Review Focused on Unmet Clinical Needs and the Multidisciplinary Approach.Journal of cardiovascular development and disease · 2026Review
- Nomogram-based prediction of in-hospital mortality and embolic events in infective endocarditis.Frontiers in microbiology · 2026Article
- Infective Endocarditis and Antimicrobial Timing: A Case for Delay?Open forum infectious diseases · 2025Article
- The impact of thrombocytopenia on mortality in infective endocarditis - aInternational journal of cardiology. Heart & vasculature · 2025Review
- Article
- Correlation Between Blood Culture Time to Positivity and Vegetation Size inAntibiotics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEchocardiographic evaluation of vegetations is crucial in infective endocarditis (IE). Although several studies have noted a link between larger vegetations and an increased risk of embolization, a more comprehensive evaluation of vegetation characteristics in a contemporary cohort has not been conducted. Our study aimed to define the short-term risk of symptomatic embolization in patients with IE. METHODS AND
resultsThe Mayo Clinic IE registry was screened to identify patients from 2015 to 2021 who had undergone transesophageal echocardiography. Multivariable subdistribution hazards regression analysis was used to identify factors associated with the cumulative incidence of symptomatic embolism over 30 days accounting for the competing risk of death. Overall, 779 patients with IE were included, of whom 517 (66.4%) were men, median age was 65.0 (interquartile range, 52.9-74.8) years, and 89.3% were White. In total, 234 patients had a symptomatic embolic event, a 30-day cumulative incidence of 30.2%. In multivariable analysis, a highly mobile vegetation was the strongest predictor of embolism (
conclusionsHighly mobile, larger vegetations are associated with embolic events. Embolic risk could be assessed by evaluating length as a continuous variable, alongside other echocardiographic findings, using a newly developed scoring tool; external validation is warranted.
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