Evidence map›Paper›PMID 39846189›Full record

ArticleZoological research2025

DNA2 knockout aggravates cerebral ischemia/reperfusion injury by reducing postsynaptic Homer1a.

Ting Ma, Yu-Meng Li, Peng-Yu Ren, Shi-Quan Wang, Xiang-Long Liu, Wen-Bo Lv, Wu-Gang Hou, Wen-Qiang Zuo, Wei-Qiang Lin, Jian Sima and 1 more

Abstract read
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In one paragraph

Article in Zoological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ting MaLaboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.
Yu-Meng LiDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Peng-Yu RenResearch & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, Guangdong 518057, China.
Shi-Quan WangDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Xiang-Long LiuResearch & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, Guangdong 518057, China.
Wen-Bo LvResearch & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, Guangdong 518057, China.
Wu-Gang HouDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Wen-Qiang ZuoDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Wei-Qiang LinInternational Institutes of Medicine, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, Zhejiang 322023, China.
Jian SimaLaboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, China. E-mail: simajian@cpu.edu.cn.
An-Qi GengResearch & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, Guangdong 518057, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA2, a multifunctional enzyme with structure-specific nuclease, 5

Indexed as

Brain IschemiaDNA HelicasesHomer Scaffolding ProteinsReperfusion InjuryAnimalsGene Expression RegulationInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLMice, KnockoutDNA HelicasesHomer1 protein, mouseHomer Scaffolding ProteinsCerebral I/RDNA2Homer1aNeuronal apoptosisOGD/R

Identifiers

PMID39846189
PMCPMC11890998

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.