ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2025
Correlation of zero echo time functional MRI with neuronal activity in rats.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Brain-wide fMRI responses to auditory and visual stimuli in awake mice.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Task-Evoked Functional Activation and Coupling With CSF Flow Detected in the Human Brain With Ultrashort Echo Time fMRI at 7 T.NMR in biomedicine · 2026Article
- Mapping cardiac and respiratory pulsations simultaneously with functional connectivity in the rat brain using zero echo time fMRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Longitudinal Awake Mouse fMRI During Voluntary Locomotion Using Zero TE Imaging and a Novel Treadmill Training Protocol.Magnetic resonance in medicine · 2026Article
- Technical considerations of functional MRI in deep brain stimulation: recent advances and future perspectives.NeuroImage · 2026Review
- Outlook on zero/ultrashort echo time techniques in functional MRI.Magnetic resonance in medicine · 2026Review
- TMagnetic resonance in medicine · 2026Article
- Simultaneous zero echo time fMRI of rat brain and spinal cord.Magnetic resonance in medicine · 2025Article
- Whisker pad stimulation with different frequencies reveals non-uniform modulation of functional MRI signal across sensory systems in awake rats.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Simultaneous zero echo time fMRI of rat brain and spinal cord.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
Zero echo time (zero-TE) pulse sequences provide a quiet and artifact-free alternative to conventional functional magnetic resonance imaging (fMRI) pulse sequences. The fast readouts (<1 ms) utilized in zero-TE fMRI produce an image contrast with negligible contributions from blood oxygenation level-dependent (BOLD) mechanisms, yet the zero-TE contrast is highly sensitive to brain function. However, the precise relationship between the zero-TE contrast and neuronal activity has not been determined. Therefore, we aimed to derive a function to model the temporal dynamics of the zero-TE fMRI signal in response to neuronal activity. Furthermore, we examined the correlation of zero-TE fMRI with neuronal activity across stimulation frequencies. To these ends, we performed simultaneous electrophysiological recordings and zero-TE fMRI in rats subjected to whisker stimulation. The presented impulse response function provides a basis for the statistical modeling of neuronal activity-induced changes in the zero-TE fMRI signal. The temporal characteristics of the zero-TE fMRI response were found to be consistent with the previously postulated non-BOLD hemodynamic origin of the functional contrast. The zero-TE fMRI signal was well predicted by electrophysiological recordings, although systematic stimulation-dependent residuals were also observed, suggesting nonlinearities in neurovascular coupling. We conclude that zero-TE fMRI provides a robust proxy for neuronal activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.