Evidence map›Paper›PMID 39846122›Full record

ArticleHead & neck2025

Oncological Feasibility of Limited Neck Dissection in cN0 Supraglottic Laryngeal Cancer.

Sara Bassani, Giacomo Papi, Filippo Marani, Riccardo Nocini, Valentina Campagnari, Filippo Marchi, Marco Lionello, Chiara Varago, Alberto Paderno, Erika Crosetti and 33 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Quantitative analysis of midline involvement for predicting contralateral cervical lymph node metastasis in supraglottic and glottic squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  3. The neck matters: optimising lymph node management in laryngeal cancer.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Sara BassaniOtolaryngology-Head and Neck Surgery Department, University of Verona, Verona, Italy.ORCID 0000-0002-3027-5967
Giacomo PapiOtolaryngology-Head and Neck Surgery Department, University of Verona, Verona, Italy.
Filippo MaraniAzienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
Riccardo NociniOtolaryngology-Head and Neck Surgery Department, University of Verona, Verona, Italy.
Valentina CampagnariUnit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID 0009-0008-8311-2732
Filippo MarchiUnit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Marco LionelloUnit of Otorhinolaryngology, Vittorio Veneto Hospital, Vittorio Veneto, Italy.
Chiara VaragoUnit of Otorhinolaryngology, Vittorio Veneto Hospital, Vittorio Veneto, Italy.
Alberto PadernoDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Erika CrosettiENT Department, University of Turin, Head and Neck Cancer Unit, San Giovanni Bosco Hospital, Turin, Italy.ORCID 0000-0003-4340-9677
Francesco MattioliDepartment of Otolaryngology Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Edoardo SerafiniDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Matteo FermiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.ORCID 0000-0002-2727-0321
Alessandro RostiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Gerardo PetruzziDepartment of Otolaryngology-Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.ORCID 0000-0003-0371-7667
Flaminia CampoDepartment of Otolaryngology-Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.ORCID 0000-0002-9249-7573
Elisa BelliniUnit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Alberto Vito MarcuzzoDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
Chiara Angela MineoDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
Giuseppe MercanteDepartment of Biomedical Sciences, Humanitas University, Milano, Italy.ORCID 0000-0002-1009-7892
Armando De VirgilioDepartment of Sense Organs, 'Sapienza' University of Rome, Rome, Italy.ORCID 0000-0003-0738-8223
Leone GiordanoDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0001-9094-4205
Andrea GalliDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Giuditta MannelliDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Luca MazzettiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Gaetano PaludettiOtorhinolaryngology Unit, A. Gemelli University Hospital Foundation IRCCS, Rome, Italy.
Giorgia RossiOtorhinolaryngology Unit, A. Gemelli University Hospital Foundation IRCCS, Rome, Italy.
Karol ZeleníkDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospital Ostrava and Faculty of Medicine, Ostrava, Czech Republic.
Daniel Marin RamosDepartment of Head and Neck Surgery, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Rogèrio Aparecido DedivitisDepartment of Head and Neck Surgery, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.ORCID 0000-0002-6267-1147
Giovanni SuccoENT Department, University of Turin, Head and Neck Cancer Unit, San Giovanni Bosco Hospital, Turin, Italy.
Giancarlo TirelliDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
Mario BussiDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Raul PelliniDepartment of Otolaryngology-Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Jacopo GalliOtorhinolaryngology Unit, A. Gemelli University Hospital Foundation IRCCS, Rome, Italy.
Giuseppe SprianoDepartment of Biomedical Sciences, Humanitas University, Milano, Italy.
Daniele MonzaniOtolaryngology-Head and Neck Surgery Department, University of Verona, Verona, Italy.
Giorgio PerettiUnit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Andy BertolinUnit of Otorhinolaryngology, Vittorio Veneto Hospital, Vittorio Veneto, Italy.
Cesare PiazzaDepartment of Surgical and Medical Specialties, Radiological Sciences, and Public Health, Unit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.ORCID 0000-0002-2391-9357
Daniele MarchioniDepartment of Otolaryngology Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Livio PresuttiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Gabriele MolteniDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSupraglottic squamous cell carcinoma (SCC) is a significant portion of head and neck cancers, with the management of clinically negative necks (cN0) through selective neck dissection (SND) being debated due to potential morbidities and low metastasis rates in levels IIb and IV.

methodsThis study is a retrospective, multicenter examination of the potential feasibility of limited neck dissection (LND), including only levels IIa and III in cN0 supraglottic SCC patients. It analyzed occult metastasis rates and explored relapse occurrences alongside potential predictors of lymph node metastasis.

resultsAmong 425 patients, predominantly male (85.6%) with a mean age of 63 years, the occult metastasis rate was 28.9%, and 13.7% experienced relapses during a mean follow-up of 52 months. Advanced clinical stage, higher grading, and other risk factors emerged as predictors of occult lymph node metastasis at level IIb.

conclusionsThe study supports LND potential feasibility for cN0 supraglottic SCC, suggesting level IIb dissection can be omitted in specific early-stage cases to reduce morbidity without affecting outcomes.

Indexed as

Carcinoma, Squamous CellLaryngeal NeoplasmsNeck DissectionAdultAgedAged, 80 and overFeasibility StudiesFemaleHumansLymphatic MetastasisMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingRetrospective StudiesTreatment Outcomeclinically negative necklarynxlimited neck dissectionoccult metastasissupraglottis

Identifiers

PMID39846122
PMCPMC12068534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.