Evidence map›Paper›PMID 39845954›Full record

ArticleFrontiers in immunology2024

Drp1-associated genes implicated in sepsis survival.

Marissa D Pokharel, Anlin Feng, Ying Liang, Wenli Ma, Saurabh Aggarwal, Hoshang Unwalla, Stephen M Black, Ting Wang

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marissa D Pokharel *Center for Translational Science, Florida International University, Port Saint Lucie, FL, United States.
Anlin Feng *Center for Translational Science, Florida International University, Port Saint Lucie, FL, United States.
Ying LiangCenter for Translational Science, Florida International University, Port Saint Lucie, FL, United States.
Wenli MaCenter for Translational Science, Florida International University, Port Saint Lucie, FL, United States.
Saurabh AggarwalDepartment of Cellular and Molecular Medicine, Florida International University, Miami, FL, United States.
Hoshang UnwallaDepartment of Cellular and Molecular Medicine, Florida International University, Miami, FL, United States.
Stephen M BlackCenter for Translational Science, Florida International University, Port Saint Lucie, FL, United States.
Ting WangCenter for Translational Science, Florida International University, Port Saint Lucie, FL, United States.

Funding

TGF-ß-SOX18-Collagen metabolism in pulmonary vascular disease associated with CHDP01HL146369 · NHLBI · UNIVERSITY OF ARIZONA · PI JEFFREY R FINEMAN · 2020 to 2026
$18.7M
Protein Chemistry & Biophysics CoreP01HL134610 · NHLBI · UNIVERSITY OF ARIZONA · PI BLACK, STEPHEN M · 2018 to 2022
$11.6M
Mechanisms of Defective Mitophagy and cellular Senescence in HIV-associated COPDR01HL147715 · NHLBI · FLORIDA INTERNATIONAL UNIVERSITY · PI IRFAN RAHMAN, HOSHANG JEHANGIR UNWALLA · 2019 to 2026
$2.6M
Resetting the Clock in HIV associated COPDR01HL158316 · NHLBI · FLORIDA INTERNATIONAL UNIVERSITY · PI RAHMAN, IRFAN, UNWALLA, HOSHANG JEHANGIR · 2022 to 2025
$2.1M
Chronic Widespread Pain in HIV: Novel Mechanisms and TherapeuticsR01DA049657 · NIDA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGGARWAL, SAURABH · 2021 to 2025
$1.8M
Identification of AMD3100 (Plerixafor) as a potential lead compound for chlorine toxicityU01ES033265 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGGARWAL, SAURABH · 2021 to 2023
$1.3M
FIU-Diversity Center for Genomic Research (FIU-DCGR)UG3HG013615 · NHGRI · FLORIDA INTERNATIONAL UNIVERSITY · PI BLACK, STEPHEN M, WANG, XUEXIA · 2024 to 2024
$817k
NHGRI NIH HHS UG3 HG013615NHLBI NIH HHS P01 HL134610NHLBI NIH HHS P01 HL146369NHLBI NIH HHS R01 HL147715NHLBI NIH HHS R01 HL158316NIDA NIH HHS R01 DA049657NIEHS NIH HHS U01 ES033265
6 · The paper itself

Abstract

Sepsis is a severe and life-threatening medical syndrome that can lead to organ failure and death. Despite advances in medical treatment, current therapies are often inadequate, with high septic mortality rates. Therefore, there is a critical need for reliable prognostic markers to be used in clinical settings to improve the management and outcomes of patients with sepsis. Recent studies have suggested that mitochondrial dynamics, including the processes of mitochondrial fission and fusion, are closely related to the severity of sepsis and the status of inflammation. By monitoring transcriptomic signals related to mitochondrial dynamics, new and reliable biomarkers can be engineered to more accurately predict sepsis survival risk. Such biomarkers would be invaluable in clinical settings, aiding healthcare providers in the early identification of high-risk patients and improving treatment strategies. To achieve this goal, we utilized the major mitochondrial fission regulatory protein dynamin-related protein 1 (Drp1, gene code

Indexed as

DynaminsSepsisBiomarkersGene Expression ProfilingHumansMitochondrial DynamicsPrognosisProtein Interaction MapsTranscriptomeBiomarkersDNM1L protein, humanDynaminsDRP1fissioninflammationmitochondriasepsis survival

Identifiers

PMID39845954
PMCPMC11750657

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.