Evidence map›Paper›PMID 39845944›Full record

ArticleFrontiers in immunology2024

Pseudoprogression in CAR-T cell therapy for solid tumor: Case report.

Xuan Zhao, Yanfen Liu, Guohui Qin, Yan Ge, Qinglong Li, Xinfeng Chen, Ximei Tian, Yong Yu, Jiangtao Ren, Yi Zhang

Abstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. CAR T-cell therapy induced pseudoprogression.Frontiers in immunology · 2026
    Review
  3. Is Pseudo-progression post-CAR T therapy real?Clinical hematology international · 2026
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuan Zhao *Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yanfen Liu *Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Guohui Qin *Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yan Ge *Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Qinglong LiDepartment of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Xinfeng ChenBiotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ximei TianBiotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yong YuMedical Department, Nanjing Bioheng Biotech Co., Ltd., Nanjing, China.
Jiangtao RenMedical Department, Nanjing Bioheng Biotech Co., Ltd., Nanjing, China.
Yi ZhangBiotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We reported the pseudoprogression in an elderly patient with advanced gastric cancer after chimeric antigen receptor (CAR)-T cell therapy. The hepatic metastases enlarged 1 month after CAR-T cell infusion and then shrunk the next month as seen through computed tomography scanning. Based on a comprehensive evaluation that includes imaging, pathology, serum tumor markers, and clinical symptoms, we arrived at a diagnosis of pseudoprogression after CAR-T cell therapy, which has not been reported in previous studies. In this report, we provide detailed descriptions of the patient's clinical presentation, imaging findings, treatment process, and follow-up outcomes. We believe that this case holds important implications for CAR-T cell therapy research and offers valuable insights for clinical practice.

Indexed as

Immunotherapy, AdoptiveLiver NeoplasmsReceptors, Chimeric AntigenStomach NeoplasmsAgedDisease ProgressionHumansTomography, X-Ray ComputedTreatment OutcomeReceptors, Chimeric AntigenCAR-T cell therapycellular immunotherapyevaluation of therapeutic efficacygastric cancerpseudoprogression

Identifiers

PMID39845944
PMCPMC11750779

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.