Evidence map›Paper›PMID 39845905›Full record

ArticleJournal of diabetes and metabolic disorders2025

Róża Aleksandrowicz, Marek Strączkowski

Abstract read
In one paragraph

Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Róża AleksandrowiczDepartment of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Żurawia 71A, Białystok, 15-540 Poland.
Marek StrączkowskiDepartment of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Żurawia 71A, Białystok, 15-540 Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Retinoid X receptors (RXRs) are nuclear hormone receptors (NRs) functioning as transcription factors. There are three RXR isoforms: RXRA (NR2B1), RXRB (NR2B2), and RXRG (NR2B3). RXRs serve as master regulators of gene networks governing cell growth, differentiation, survival, and death. RXRs might affect insulin action, but very little data currently supports this relationship. The aim of the study was to analyze the relationship between the expression of RXRs in skeletal muscles and insulin sensitivity in young, normal-weight, overweight and obese people. Methods: The research group consisted of 45 volunteers, 20 had normal body weight, 13 were overweight, and 12 were obese. Insulin sensitivity was measured with hyperinsulinemic-euglycemic clamp. Vastus lateralis muscle biopsies were taken before each clamp, and RXRs mRNA expression was analyzed. Results: Conclusions: Our results indicate that

Indexed as

Insulin resistanceInsulin sensitivityRXRsSkeletal muscle

Identifiers

PMID39845905
PMCPMC11748634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.